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1
Concentration of homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular cerebrospinal fluid of patients with obstructive hydrocephalus.梗阻性脑积水患者脑室脑脊液中高香草酸和5-羟吲哚乙酸的浓度。
J Neurol Neurosurg Psychiatry. 1979 Jan;42(1):78-81. doi: 10.1136/jnnp.42.1.78.
2
Homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular CSF of comatose patients with obstructive hydrocephalus.梗阻性脑积水昏迷患者脑室脑脊液中的高香草酸和5-羟吲哚乙酸
J Neurosurg. 1980 May;52(5):635-41. doi: 10.3171/jns.1980.52.5.0635.
3
Monoamine acid metabolites in ventricular CSF of patients with brain tumours.脑肿瘤患者脑室脑脊液中的单胺酸代谢产物。
Acta Neurochir (Wien). 1976;35(1-3):161-70. doi: 10.1007/BF01405944.
4
[Homovanillic acid and 5--hydroxy-indoleacetic acid in the cerebrospinal fluid of man--concentration gradients between lumbar and ventricular CSF and variations in ventricular CSF-- (author's transl)].人脑脊液中的高香草酸和5-羟吲哚乙酸——腰段脑脊液与脑室脑脊液之间的浓度梯度及脑室脑脊液的变化（作者译）
No To Shinkei. 1978 May;30(5):565-74.
5
[Cerebral mediators and intracranial neoplasms].[脑介质与颅内肿瘤]
Acta Neurol (Napoli). 1975 Jan-Feb;30(1):71-7.
6
[Homovanillic (HVA) and 5-hydroxyindoleacetic (5-HIAA) acid concentration in the cerebrospinal fluid of patients with supratentorial tumors and symptoms of intracranial hypertension (preliminary report)].[幕上肿瘤伴颅内高压症状患者脑脊液中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）的浓度（初步报告）]
Neurol Neurochir Pol. 1980 Jan-Feb;14(1):87-90.
7
[Homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) levels in the cerebrospinal fluid from the lateral ventricle of patients with brain tumors].[脑肿瘤患者侧脑室脑脊液中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）水平]
Neurol Neurochir Pol. 1986 Jan-Feb;20(1):54-8.
8
Monoamine acid metabolites and cerebrospinal fluid dynamics in normal pressure hydrocephalus: preliminary results.正常压力脑积水的单胺酸代谢产物与脑脊液动力学：初步结果
J Neurol Neurosurg Psychiatry. 1975 Feb;38(2):123-8. doi: 10.1136/jnnp.38.2.123.
9
[5-HIAA and HVA levels in the cerebrospinal fluid of hydrocephalic patients].[脑积水患者脑脊液中5-羟吲哚乙酸和高香草酸水平]
Acta Neurol (Napoli). 1976 Sep-Oct;31(5):601-13.
10
Sites of origin in the central nervous system of monoamine metabolites measured in human cerebrospinal fluid.在人类脑脊液中测量的单胺代谢产物在中枢神经系统中的起源部位。
J Neurol Neurosurg Psychiatry. 1973 Aug;36(4):625-9. doi: 10.1136/jnnp.36.4.625.

本文引用的文献

1
On the occurrence of homovanillic acid in brain and cerebrospinal fluid and its determination by a fluorometric method.关于高香草酸在脑和脑脊液中的存在及其荧光法测定
Life Sci (1962). 1963 Jul(7):448-58. doi: 10.1016/0024-3205(63)90132-2.
2
Increased level of 5-hydroxyindoleacetic acid in cerebrospinal fluid from infantile hydrocephalus.婴儿脑积水患者脑脊液中5-羟吲哚乙酸水平升高。
Experientia. 1966 Aug 15;22(8):539-40. doi: 10.1007/BF01898679.
3
Measurement of acid monoamine metabolites in human and animal cerebrospinal fluid.人和动物脑脊液中酸性单胺代谢物的测量。
J Neurochem. 1968 Sep;15(9):1053-5. doi: 10.1111/j.1471-4159.1968.tb11648.x.
4
Experimental effects of free serotonin on the brain and its relation to brain injury. 1. The neurological consequences of intracerebral serotonin injections. 2. Trauma-induced alterations in spinal fluid and brain. 3. Serotonin-induced cerebral edema.游离血清素对大脑的实验性影响及其与脑损伤的关系。1. 脑内注射血清素的神经学后果。2. 创伤引起的脑脊液和大脑变化。3. 血清素诱导的脑水肿。
J Neurosurg. 1969 Oct;31(4):408-12. doi: 10.3171/jns.1969.31.4.0408.
5
Brain concentrations of dopamine, noradrenaline, 5-hydroxytryptamine, and homovanillic acid during intracranial hypertension following traumatic brain injury in rabbit.兔创伤性脑损伤后颅内高压期间脑内多巴胺、去甲肾上腺素、5-羟色胺和高香草酸的浓度
Acta Neurol Scand. 1971;47(4):458-63. doi: 10.1111/j.1600-0404.1971.tb07500.x.
6
Cerebral metabolites in cerebrospinal fluid as a biochemical approach to the brain.脑脊液中的脑代谢物作为研究大脑的生化方法。
Brain. 1970;93(2):357-68. doi: 10.1093/brain/93.2.357.
7
Monoamine metabolites in lumbar CSF: the question of their origin in relation to clinical studies.腰椎脑脊液中的单胺代谢产物：其来源与临床研究相关的问题
Brain Res. 1974 Oct 11;79(1):1-8. doi: 10.1016/0006-8993(74)90562-9.
8
Norepinephrine metabolism in the central nervous system of man: studies using 3-methoxy-4-hydroxyphenylethylene glycol levels in cerebrospinal fluid.人类中枢神经系统中的去甲肾上腺素代谢：利用脑脊液中3-甲氧基-4-羟基苯乙二醇水平的研究
J Neurochem. 1973 Sep;21(3):581-7. doi: 10.1111/j.1471-4159.1973.tb06003.x.
9
Comparative effects of p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid.对氯苯丙胺和对氯-N-甲基苯丙胺对大鼠脑去甲肾上腺素、5-羟色胺和5-羟吲哚-3-乙酸的比较作用。
Biochem Pharmacol. 1970 Feb;19(2):435-42. doi: 10.1016/0006-2952(70)90199-1.
10
Homovanillic acid and 5-hydroxyindole-acetic acid in the csf of patients after a severe head injury. II. Ventricular csf concentrations in acute brain post-traumatic syndromes.重型颅脑损伤患者脑脊液中的高香草酸和5-羟吲哚乙酸。II. 急性脑外伤后综合征患者脑室脑脊液浓度
Eur Neurol. 1975;13(6):545-54. doi: 10.1159/000114710.

梗阻性脑积水患者脑室脑脊液中高香草酸和5-羟吲哚乙酸的浓度。

Concentration of homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular cerebrospinal fluid of patients with obstructive hydrocephalus.

作者信息

Kmieciak-Kolada K, Majchrzak H, Herman Z S

出版信息

J Neurol Neurosurg Psychiatry. 1979 Jan;42(1):78-81. doi: 10.1136/jnnp.42.1.78.

DOI:10.1136/jnnp.42.1.78
PMID:216782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC490163/
Abstract

In 12 patients with different posterior fossa tumours the concentrations of homovanillic acid (HVA) and of 5-hydroxyindoleacetic acid (5-HIAA) were measured in cerebrospinal fluid from the lateral ventricles. All patients had obstructive hydrocephalus. Patients with a clear increase of 5-HIAA/HVA ratio in the ventricular CSF have died subsequently. This feature may have a diagnostic value, and indicates the prevalence of serotoninergic neurones in patients with obstructive hydrocephalus with fatal course after surgery.

摘要

在12例患有不同后颅窝肿瘤的患者中，测量了侧脑室脑脊液中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）的浓度。所有患者均患有梗阻性脑积水。脑室脑脊液中5-HIAA/HVA比值明显升高的患者随后均死亡。这一特征可能具有诊断价值，并表明在术后病程致命的梗阻性脑积水患者中，5-羟色胺能神经元占优势。