梗阻性脑积水患者脑室脑脊液中高香草酸和5-羟吲哚乙酸的浓度。
Concentration of homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular cerebrospinal fluid of patients with obstructive hydrocephalus.
作者信息
Kmieciak-Kolada K, Majchrzak H, Herman Z S
出版信息
J Neurol Neurosurg Psychiatry. 1979 Jan;42(1):78-81. doi: 10.1136/jnnp.42.1.78.
Abstract
In 12 patients with different posterior fossa tumours the concentrations of homovanillic acid (HVA) and of 5-hydroxyindoleacetic acid (5-HIAA) were measured in cerebrospinal fluid from the lateral ventricles. All patients had obstructive hydrocephalus. Patients with a clear increase of 5-HIAA/HVA ratio in the ventricular CSF have died subsequently. This feature may have a diagnostic value, and indicates the prevalence of serotoninergic neurones in patients with obstructive hydrocephalus with fatal course after surgery.
摘要
在12例患有不同后颅窝肿瘤的患者中，测量了侧脑室脑脊液中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）的浓度。所有患者均患有梗阻性脑积水。脑室脑脊液中5-HIAA/HVA比值明显升高的患者随后均死亡。这一特征可能具有诊断价值，并表明在术后病程致命的梗阻性脑积水患者中，5-羟色胺能神经元占优势。
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