Kellman Peter, Chung Yiu-Cho, Simonetti Orlando P, McVeigh Elliot R, Arai Andrew E
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892-1061, USA.
J Magn Reson Imaging. 2005 Nov;22(5):605-13. doi: 10.1002/jmri.20426.
To develop and test a delayed-enhancement imaging method for improving the contrast between myocardial infarction (MI) and blood pool.
The T(2) of blood is significantly longer than that of acute or chronic MI. The proposed multi-contrast delayed-enhancement (MCODE) imaging method produces a series of images with both T(1) and T(2) weightings, which provides both excellent contrast between normal and infarcted myocardium, and between blood and MI.
The subendocardial border between MI and blood pool was easily discriminated in the T(2)-weighted image. The measured MI-to-blood contrast-to-noise ratio (CNR) was better in the T(2)-weighted image than in the T(1)-weighted image (22.5+/-8.7 vs. 2.9+/-3.1, mean+/-SD, N=11, P<0.001, for True FISP, and 19.4+/-10.8 vs. 3.9+/-2.3, N=11, P<0.001, for Turbo FLASH).
The MCODE method provides a significant improvement in the ability to easily discriminate subendocardial MI by providing a T(2)-weighted image with high contrast between blood and MI. MCODE should improve both the detection and accurate sizing of MI.
开发并测试一种延迟增强成像方法，以提高心肌梗死（MI）与血池之间的对比度。
血液的T(2)明显长于急性或慢性MI的T(2)。所提出的多对比度延迟增强（MCODE）成像方法可生成一系列具有T(1)和T(2)加权的图像，这既能在正常心肌与梗死心肌之间，也能在血液与MI之间提供出色的对比度。
在T(2)加权图像中，MI与血池之间的心内膜下边界很容易区分。在T(2)加权图像中测得的MI与血液的对比噪声比（CNR）优于T(1)加权图像（对于True FISP，分别为22.5±8.7和2.9±3.1，均值±标准差，N = 11，P<0.001；对于Turbo FLASH，分别为19.4±10.8和3.9±2.3，N = 11，P<0.001）。
MCODE方法通过提供血液与MI之间具有高对比度的T(2)加权图像，在轻松区分心内膜下MI的能力方面有显著提高。MCODE应能改善MI的检测及准确测量大小。
