McKenzie Shaun, Kyprianou Natasha
Department of Surgery/Urology, University of Kentucky Medical Center, Lexington, KY, USA.
J Cell Biochem. 2006 Jan 1;97(1):18-32. doi: 10.1002/jcb.20634.
The ability of a tumor cell population to grow exponentially represents an imbalance between cellular proliferation and cellular attrition. There is an overwhelming body of evidence suggesting the ability of tumor cells to avoid programmed cellular attrition, or apoptosis, is a major molecular force driving the progression of human tumors. Apoptotic evasion represents one of the true hallmarks of cancer and appears to be a vital component in the immunogenic, chemotherapeutic, and radiotherapeutic resistance that characterizes the most aggressive of human cancers [Hanahan and Weinberg, 2000]. The challenges in the development of effective treatment modalities for advanced prostate cancer represent a classic paradigm of the functional significance of anti-apoptotic pathways in the development of therapeutic resistance.
肿瘤细胞群体呈指数增长的能力代表了细胞增殖与细胞损耗之间的失衡。大量证据表明，肿瘤细胞避免程序性细胞损耗即凋亡的能力是推动人类肿瘤进展的主要分子力量。凋亡逃避是癌症的真正标志之一，并且似乎是最具侵袭性的人类癌症所具有的免疫原性、化疗和放疗抗性的重要组成部分[哈纳汉和温伯格，2000年]。晚期前列腺癌有效治疗方式研发面临的挑战代表了抗凋亡途径在治疗抗性发展中的功能意义的经典范例。
