Ouzounis Christos A
Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK.
Curr Opin Genet Dev. 2005 Dec;15(6):595-600. doi: 10.1016/j.gde.2005.09.011. Epub 2005 Oct 7.
The recent expansion of phylogenetic analysis from the traditional field of molecular evolution, analyzing histories of genes, to the nascent field of "genomic evolution", analyzing histories of entire genomes, enables the construction of trees based on genome information, the quantification of the key processes that shape genome content and, ultimately, plausible parsimony reconstructions of ancestral genomes. Thus, when genomes are considered as phylogenetic characters, it is possible to reconstruct not only the history of species but also the ancestral states in terms of genome structure or function. In the future, we might be able to accurately reconstruct--or retrodict--a chain of events that led to the emergence of a specific genome sequence and, ultimately, to synthesize ancestral genomes at will, creating a "Jurassic database" of genomes.
系统发育分析最近已从传统的分子进化领域（分析基因历史）扩展到新兴的“基因组进化”领域（分析整个基因组的历史），这使得基于基因组信息构建树状图、量化塑造基因组内容的关键过程，并最终对祖先基因组进行合理的简约性重建成为可能。因此，当将基因组视为系统发育特征时，不仅有可能重建物种的历史，还能根据基因组结构或功能重建祖先状态。未来，我们或许能够准确地重建——或追溯——导致特定基因组序列出现的一系列事件，并最终随意合成祖先基因组，创建一个基因组的“侏罗纪数据库”。
