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在东经23°及稍偏东的地区发展计算生物学。

Developing computational biology at meridian 23° E, and a little eastwards.

作者信息

Ouzounis Christos A

机构信息

Biological Computation & Process Laboratory (BCPL), Chemical Process & Energy Resources Institute (CPERI), Centre for Research & Technology Hellas (CERTH), PO Box 361, 57001 Thessaloníki, Greece.

出版信息

J Biol Res (Thessalon). 2018 Nov 14;25:18. doi: 10.1186/s40709-018-0091-5. eCollection 2018 Dec.

Abstract

Modern biology is experiencing a deep transformation by the expansion of molecular-level measurements at all scales, using omics technologies. A key element in this transformation is the field of bioinformatics, that has-in the meanwhile-permeated pretty much all of biological and biomedical research and is now emerging as a key inter-disciplinary area that connects the natural sciences, chemical and electrical engineering, science education and science policy, on a number of science and technology fronts. The strong tradition of open access for large volumes of raw data, collections of complex results and high-quality algorithm implementations in bioinformatics makes the field a unique, special case of open science. We report on our recent research activities, the development of training initiatives in the wider region during the past years, and the lessons learned regarding our efforts away from major epicenters, within the general context of open science.

摘要

现代生物学正经历着一场深刻的变革,这一变革源于利用组学技术在各个尺度上扩展分子水平的测量。这场变革中的一个关键因素是生物信息学领域,在此期间,该领域几乎渗透到了所有生物和生物医学研究中,如今正作为一个关键的跨学科领域崭露头角,它在多个科学和技术前沿领域连接着自然科学、化学与电气工程、科学教育以及科学政策。生物信息学领域对大量原始数据、复杂结果集合以及高质量算法实现进行开放获取的悠久传统,使其成为开放科学领域中一个独特的特殊案例。我们报告了我们近期的研究活动、过去几年在更广泛区域开展的培训计划的发展情况,以及在开放科学的总体背景下,我们在远离主要中心地区所做努力中吸取的经验教训。

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