Hazle John D, Stafford R Jason, Price Roger E
Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
J Magn Reson Imaging. 2002 Feb;15(2):185-94. doi: 10.1002/jmri.10055.
To further investigate the use of magnetic resonance-guided focused ultrasound therapy (MRgFUS) as a noninvasive alternative to surgery in the local control of soft-tissue tumors by ablating prescribed volumes of VX2 rabbit tumors and comparing with ablation of normal tissue volumes.
Small, ellipsoidal ablations at shallow depth were created using 5- to 15-second sonication pulses at radio frequency (RF) powers of 50-125 W using a spherical, air-backed transducer operating at 1.463 MHz under MR guidance in a 1.5-T clinical scanner.
Excellent correlation was observed between prescribed treatment volumes, MR thermal dosimetry, post-treatment verification MRI, and histopathology. Multifocal ablations of VX2 tumors in rabbits at depths of up to 2.5 cm resulted in complete ablation of the prescribed treatment volume.
MRgFUS is an effective technique for treating tumors in vivo. Techniques developed for treatments in homogeneous tissue volumes are applicable in the more complicated tumor environment if MR temperature feedback is available to modify treatment delivery parameters.
通过消融规定体积的VX2兔肿瘤并与正常组织体积的消融进行比较，进一步研究磁共振引导聚焦超声治疗（MRgFUS）作为软组织肿瘤局部控制中手术的非侵入性替代方法的应用。
在1.5-T临床扫描仪的MR引导下，使用在1.463 MHz下工作的球形空气背衬换能器，以50-125 W的射频（RF）功率进行5至15秒的超声脉冲，在浅深度创建小的椭圆形消融灶。
在规定的治疗体积、MR热剂量测定、治疗后验证MRI和组织病理学之间观察到极好的相关性。在兔体内对深度达2.5 cm的VX2肿瘤进行多灶消融导致规定治疗体积的完全消融。
MRgFUS是一种治疗体内肿瘤的有效技术。如果有MR温度反馈来修改治疗传递参数，为均匀组织体积治疗开发的技术可应用于更复杂的肿瘤环境。
