Carr M M, Best T J, Mackinnon S E, Evans P J
Department of Surgery, University of Toronto, Ontario, Canada.
Ann Plast Surg. 1992 Jun;28(6):538-44.
The degree of self-mutilation (autotomy) following sciatic nerve injury was assessed in 6 rat strains. Experimental groups included sciatic nerve transection with and without repair and crush lesions. The degree of autotomy was measured using a standard grading system. There were statistically significant differences between the strains in the transected group in terms of both degree of autotomy and the time of onset of its appearance. The repair group showed a shorter mean time of onset, lower maximal scores, and lower percentage of affected animals. Autotomy was absent in the nerve crush group and in all Lewis rats. In experimental studies when the status of the foot is critical (e.g., to evaluate functional walking patterns) Lewis rats appear to be the most appropriate strain to utilize. These results suggest that there are definite strain differences in the degree of autotomy following nerve transection or repair.
在6个大鼠品系中评估了坐骨神经损伤后的自残（自切）程度。实验组包括坐骨神经切断术（有修复和无修复）以及挤压损伤。使用标准分级系统测量自切程度。在切断组中，各品系之间在自切程度及其出现时间方面存在统计学显著差异。修复组的平均发病时间较短、最高得分较低且受影响动物的百分比也较低。神经挤压组和所有Lewis大鼠均未出现自切现象。在实验研究中，当足部状况至关重要时（例如，评估功能性行走模式），Lewis大鼠似乎是最适合使用的品系。这些结果表明，神经切断或修复后自切程度存在明确的品系差异。
