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肝脏免疫学与草药治疗

Liver immunology and herbal treatment.

作者信息

Balaban Yasemin H, Aka Ceylan, Koca-Caliskan Ufuk

机构信息

Yasemin H Balaban, Gastroenterology Unit, Private Etimed Hospital, 06790 Ankara, Turkey.

出版信息

World J Hepatol. 2017 Jun 18;9(17):757-770. doi: 10.4254/wjh.v9.i17.757.

DOI:10.4254/wjh.v9.i17.757
PMID:28660010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5474722/
Abstract

Beyond the metabolic functions, the liver recently has been defined as an organ of immune system (IS), which have central regulatory role for innate and adaptive immunity. The liver keeps a delicate balance between hepatic screening of pathogenic antigens and immune tolerance to self-antigens. Herbal treatments with immunological effects have potential to alter this hepatic immune balance towards either therapeutic side or diseases side by inducing liver injury hepatotoxicity or initiation of autoimmune diseases. Most commonly known herbal treatments, which have therapeutic effect on liver and IS, have proven , , and/or clinical studies were summarized in this review.

摘要

除了代谢功能外,肝脏最近被定义为免疫系统(IS)的一个器官,它对先天性免疫和适应性免疫具有核心调节作用。肝脏在对病原性抗原的肝脏筛选和对自身抗原的免疫耐受之间保持着微妙的平衡。具有免疫作用的草药治疗有可能通过诱导肝损伤、肝毒性或引发自身免疫性疾病,使这种肝脏免疫平衡朝着治疗或疾病方向改变。本文综述了最常见的、对肝脏和免疫系统有治疗作用的草药治疗,这些治疗已得到证实、[此处可能有缺失内容]和/或临床研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad0/5474722/73dd7996e80e/WJH-9-757-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad0/5474722/73dd7996e80e/WJH-9-757-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad0/5474722/73dd7996e80e/WJH-9-757-g001.jpg

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2
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Hepatology. 2017 Jan;65(1):363-373. doi: 10.1002/hep.28813. Epub 2016 Nov 17.
3
The hygiene hypothesis: current perspectives and future therapies.卫生假说:当前观点与未来疗法
酒精性肝病中免疫细胞作用的最新研究进展。
Front Immunol. 2019 Jun 12;10:1328. doi: 10.3389/fimmu.2019.01328. eCollection 2019.
4
Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway.黄芪甲苷通过激活 Nrf2 信号通路减轻对乙酰氨基酚诱导的小鼠肝损伤。
Molecules. 2018 Aug 14;23(8):2032. doi: 10.3390/molecules23082032.
5
Cuscuta arvensis Beyr "Dodder": In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity in Rats.田野菟丝子(Cuscuta arvensis Beyr)“菟丝子”:对大鼠对乙酰氨基酚诱导的肝毒性的体内保肝作用。
J Med Food. 2018 Jun;21(6):625-631. doi: 10.1089/jmf.2017.0139. Epub 2018 May 2.
Immunotargets Ther. 2015 Jul 27;4:143-57. doi: 10.2147/ITT.S61528. eCollection 2015.
4
Immunopathogenesis of IBD: current state of the art.炎症性肠病的免疫发病机制:最新进展。
Nat Rev Gastroenterol Hepatol. 2016 Jan;13(1):13-27. doi: 10.1038/nrgastro.2015.186. Epub 2015 Dec 2.
5
Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications.特异质性药物性肝损伤的适应与进展机制及其临床意义
Liver Int. 2016 Feb;36(2):158-65. doi: 10.1111/liv.12988. Epub 2015 Nov 11.
6
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7
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J Ethnopharmacol. 2015 Jul 1;169:244-62. doi: 10.1016/j.jep.2015.03.067. Epub 2015 Apr 6.
9
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Curr Probl Pediatr Adolesc Health Care. 2014 Dec;44(11):322-3. doi: 10.1016/j.cppeds.2014.10.001. Epub 2014 Nov 26.
10
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Afr J Tradit Complement Altern Med. 2014 Apr 3;11(3):102-6. doi: 10.4314/ajtcam.v11i3.15. eCollection 2014.