Wang C J, Tseng T H, Lin J K
Department of Biochemistry, Chung Shan Medical and Dental College, Taichung, Taiwan, R.O.C.
Anticancer Res. 1992 May-Jun;12(3):911-5.
A new compound, penta-acetyl geniposide [(Ac)5-GP], was obtained from modified extract of Gardenia Fructus (San-jee-chee in Chinese). Spectral studies including ultraviolet (UV), mass (MS), nuclear magnetic resonance (NMR), infrared (IR) and elemental analysis (EA) have suggested the chemical structure of the compound as 1-(beta-D-2',3',4',6'-tetraacetyl- glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(acetomethyl)-c yclopentapyran-4-carboxylic acid methyl ester. The antitumor bioactivity of (Ac)5-GP in vitro was studied. It exhibited the activities of reduced plating efficiency and inhibition of DNA synthesis in cultured C-6 glioma cells, but had little effect on RNA and protein synthesis. These results implied that the acetylated iridoid glycoside of Gardenia Fructus is biologically active as an antitumor agent against C-6 glioma cells in culture.
从栀子（中文名为“山栀子”）的改良提取物中获得了一种新化合物，五乙酰京尼平苷[（Ac）5 - GP]。包括紫外光谱（UV）、质谱（MS）、核磁共振（NMR）、红外光谱（IR）和元素分析（EA）在内的光谱研究表明，该化合物的化学结构为1 - （β - D - 2'，3'，4'，6' - 四乙酰 - 吡喃葡萄糖氧基）- 1，4a，5，7a - 四氢 - 7 - （乙酰甲基）- 环戊并吡喃 - 4 - 羧酸甲酯。研究了（Ac）5 - GP在体外的抗肿瘤生物活性。它在培养的C - 6胶质瘤细胞中表现出降低平板接种效率和抑制DNA合成的活性，但对RNA和蛋白质合成影响很小。这些结果表明，栀子的乙酰化环烯醚萜苷作为一种针对培养的C - 6胶质瘤细胞的抗肿瘤剂具有生物活性。
