Fulimoto T, Maeda H, Kubo K, Sugita Y, Nakashima T, Sato E, Tanaka Y, Madachi M, Aiba M, Kameyama Y
Department of Pathology, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
J Int Med Res. 2005 Sep-Oct;33(5):507-12. doi: 10.1177/147323000503300505.
The aim of this study was to determine the effects of low-voltage electrochemotherapy with intraperitoneal cisplatin on hamster oral fibrosarcoma. Oral fibrosarcoma was transplanted submucosally into the cheek pouch mucosa of 100 hamsters. After transplantation, the hamsters were randomly divided into four equal groups. These groups received no treatment (D-E-); 2 mg/kg body weight cisplatin treatment without electroporation (D+E-); electroporation without cisplatin treatment (D-E+); or 2 mg/kg body weight cisplatin treatment followed by electroporation (D+E+). Electrical pulse treatment together with cisplatin injection markedly reduced the size of the tumour, whereas cisplatin injection or electrical pulse treatment alone did not. These results clearly indicate that the anti-tumour effect of cisplatin on hamster oral fibrosarcoma was considerably potentiated or enhanced by the administration of local electrical pulses at low voltages.
本研究的目的是确定腹腔注射顺铂的低电压电化学疗法对仓鼠口腔纤维肉瘤的影响。将口腔纤维肉瘤黏膜下移植到100只仓鼠的颊囊黏膜中。移植后，将仓鼠随机分为四组，每组数量相等。这些组分别接受无治疗（D-E-）；2mg/kg体重顺铂治疗但不进行电穿孔（D+E-）；不进行顺铂治疗只进行电穿孔（D-E+）；或2mg/kg体重顺铂治疗后进行电穿孔（D+E+）。电脉冲治疗联合顺铂注射显著减小了肿瘤大小，而单独的顺铂注射或电脉冲治疗则没有这种效果。这些结果清楚地表明，低电压局部电脉冲给药可显著增强顺铂对仓鼠口腔纤维肉瘤的抗肿瘤作用。
