Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, New York, USA.
J Leukoc Biol. 2019 Jul;106(1):193-200. doi: 10.1002/JLB.4MIR1118-439R. Epub 2019 Feb 18.
The oral cavity is a unique environment containing teeth juxtaposed with soft tissues, all of which are constantly bathed in microbial products and host-derived factors. While microbial dysbiosis in the oral cavity clearly leads to oral inflammatory disease, recent advances find that endogenous danger-associated molecular patterns (DAMPs) released from oral and salivary tissue also contribute to the progression of inflammatory and autoimmune disease, respectively. In contrast, DAMPs produced during oral fungal infection actually promote the resolution of infection. Here, we present a review of the literature suggesting a role for signaling by DAMPs, which may intersect with pathogen-associated molecular pattern (PAMP) signaling, in diseases that manifest in the oral cavity, specifically periodontal disease, oropharyngeal candidiasis, and Sjögren's syndrome.
口腔是一个独特的环境，其中包含牙齿与软组织毗邻，所有这些都不断被微生物产物和宿主来源的因素所浸润。虽然口腔内微生物失调显然会导致口腔炎症性疾病，但最近的研究进展发现，来自口腔和唾液组织的内源性危险相关分子模式 (DAMP) 也分别有助于炎症性和自身免疫性疾病的进展。相比之下，口腔真菌感染过程中产生的 DAMPs 实际上促进了感染的解决。在这里，我们回顾了文献，提出了 DAMPs 信号的作用的观点，这可能与病原体相关分子模式 (PAMP) 信号交叉，参与了在口腔中表现出来的疾病，特别是牙周病、口咽念珠菌病和干燥综合征。
