糖尿病患者皮肤丙酮浓度与血液β-羟基丁酸浓度之间的关系

Relationship between skin acetone and blood beta-hydroxybutyrate concentrations in diabetes.

作者信息

Yamane Norio, Tsuda Takao, Nose Kazutoshi, Yamamoto Akiko, Ishiguro Hiroshi, Kondo Takaharu

机构信息

Research Center of Health, Physical Fitness and Sports, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.

出版信息

Clin Chim Acta. 2006 Mar;365(1-2):325-9. doi: 10.1016/j.cca.2005.09.016. Epub 2005 Oct 11.

DOI:10.1016/j.cca.2005.09.016

PMID:16223475

Abstract

BACKGROUND

Acetone is emitted from the skin and acetone concentrations correlate with blood beta-hydroxybutyrate.

METHODS

Skin acetone concentrations of 63 patients with diabetes and 32 control subjects were measured by cold trapping followed by gas chromatography.

RESULTS

Skin acetone concentrations of patients with diabetes (188+/-17 ppb; mean+/-SE) were significantly higher than those of the control subjects (87+/-10 ppb, p<0.01). There was no significant difference in skin acetone concentrations among patients with diabetes with regard to mode of treatment. Skin acetone concentrations were correlated with blood beta-hydroxybutyrate (r=0.669, p<0.01), blood glucose (r=0.608, p<0.01), and HbA1c (r=0.292, p<0.05) in patients with diabetes. Skin acetone concentration was high (940 ppb) in a patient with diabetic ketoacidosis, and it fell to 80 ppb after insulin therapy.

CONCLUSION

Measurement of skin acetone can be used as a screening test for ketoacidosis provided the analytical methods and tools become simpler. Moreover, it could become a marker of diabetic control and of ketone production in diabetes and other ketogenic conditions.

摘要

背景

丙酮从皮肤排出，且丙酮浓度与血液β-羟基丁酸相关。

方法

采用冷阱捕集后气相色谱法测量63例糖尿病患者和32例对照者的皮肤丙酮浓度。

结果

糖尿病患者的皮肤丙酮浓度（188±17 ppb；均值±标准误）显著高于对照者（87±10 ppb，p<0.01）。糖尿病患者中，不同治疗方式的患者皮肤丙酮浓度无显著差异。糖尿病患者的皮肤丙酮浓度与血液β-羟基丁酸（r=0.669，p<0.01）、血糖（r=0.608，p<0.01）及糖化血红蛋白（r=0.292，p<0.05）相关。1例糖尿病酮症酸中毒患者的皮肤丙酮浓度较高（940 ppb），胰岛素治疗后降至80 ppb。