Gebauer Dieter, Mayr Edgar, Orthner Ernst, Ryaby John P
Orthopädische Klinik Tegernsee, Tegernsee, Germany.
Ultrasound Med Biol. 2005 Oct;31(10):1391-402. doi: 10.1016/j.ultrasmedbio.2005.06.002.
To study the efficacy of low-intensity pulsed ultrasound (US), or LIPUS, of 85 treated nonunion cases with a minimum fracture age of 8 months, 67 cases met the study criteria. These were: no surgical intervention during 4 months before US treatment and radiographically ceased healing for 3 months before US. In a self-paired control study, the mean fracture age of the 67 patients was 39 +/- 6.2 months. After a daily 20-min US treatment at home for an average of 168 days, 85% (57 of 67) of the nonunion cases were clinically and radiographically healed. The study did not include any cases that were malaligned, grossly instable, actively infected or that had extensive bone loss. The results demonstrate that the specific US can effect heal rates similar to those achieved by surgical means, without the associated risks and complications, and to those achieved by electrical bone growth stimulation or by extracorporeal shock-wave therapy.
为研究低强度脉冲超声（LIPUS）对85例骨折不愈合病例的疗效，这些病例骨折最短时间为8个月，其中67例符合研究标准。标准为：在接受超声治疗前4个月内未进行手术干预，且在超声治疗前经X线检查显示骨折已停止愈合3个月。在一项自身配对对照研究中，67例患者的平均骨折时间为39±6.2个月。在家中每天接受20分钟的超声治疗，平均持续168天，85%（67例中的57例）的骨折不愈合病例在临床和影像学上均已愈合。该研究未纳入任何存在骨折对位不良、严重不稳定、存在活动性感染或有大量骨质流失的病例。结果表明，特定的超声治疗可达到与手术治疗相似的愈合率，且无相关风险和并发症，与电刺激骨生长或体外冲击波治疗的愈合率相当。
