Inerot Annica, Enerbäck Charlotta, Enlund Fredrik, Martinsson Tommy, Samuelsson Lena, Wahlström Jan, Swanbeck Gunnar
Department of Dermatology, Sahlgrenska University Hospital/Sahlgrenska, SE-413 45 Göteborg, Sweden.
BMC Dermatol. 2005 Oct 14;5:10. doi: 10.1186/1471-5945-5-10.
The aim of the present study was to describe the clinical characteristics of a population of psoriatics sampled from a patient organisation and not from hospitals or out-patient clinics. Furthermore, we wanted to compare siblings with and without psoriasis regarding the occurrence of other diseases.
At the end of 1991, we initiated a project which aimed to study genetic factors leading to psoriasis. Firstly, we sent questionnaires to all the members of the Swedish Psoriasis Association. We then examined 1,217 individuals (570 with psoriasis) from 310 families, in their homes in the southern part of Sweden. All the available family members were examined clinically and asked about the course of the skin disease and the occurrence of other diseases. The eight hundred members of the proband generation were divided into two groups, with or without psoriasis, and their clinical features were compared.
Most individuals in this study population had a mild form of psoriasis. The siblings with psoriasis had joint complaints significantly more frequently than their siblings without the skin disease and those with joint complaints had more widespread skin disease. Among the other studied concomitant diseases (iritis, heart or hypertension disease, endocrine disease, inflammatory bowel disease and neurological disease), we were not able to find any difference. Seventy-seven of 570 persons were found to be in remission (13.5%). Females had a mean onset 2.5 years earlier than males. We were not able to find any correlation between the extent of the skin disease and age at onset. Twice as many persons with joint complaints were found among those with psoriasis than among those without, 28% versus 13%. Almost half (48%) the psoriatics who also had joint complaints had psoriasis lesions on their nails. Endocrine disorders were found in 9% of those without any allele for Cw6, but only in 1% of those who had Cw6. In fact, none of 183 Cw6 carriers had diabetes, as compared to the population prevalence of 3-5% in Sweden.
With the exception of joint complaints, persons with psoriasis, collected from a patient organisation, did not have an increased frequency of (studied) co-existing diseases.
本研究的目的是描述从一个患者组织而非医院或门诊收集的银屑病患者群体的临床特征。此外，我们想比较患银屑病和未患银屑病的兄弟姐妹其他疾病的发生情况。
1991年底，我们启动了一个旨在研究导致银屑病的遗传因素的项目。首先，我们向瑞典银屑病协会的所有成员发送了问卷。然后，我们在瑞典南部他们的家中对来自310个家庭的1217人（570名银屑病患者）进行了检查。所有可获得的家庭成员都接受了临床检查，并询问了皮肤病的病程和其他疾病的发生情况。先证者一代的800名成员被分为两组，有或没有银屑病，并比较了他们的临床特征。
该研究人群中的大多数个体患有轻度银屑病。患银屑病的兄弟姐妹关节不适的发生率明显高于未患皮肤病的兄弟姐妹，而有关节不适的人皮肤病分布更广。在其他研究的伴随疾病（虹膜炎、心脏病或高血压病、内分泌疾病、炎症性肠病和神经疾病）中，我们未发现任何差异。570人中77人处于缓解期（13.5%）。女性发病平均比男性早2.5年。我们未发现皮肤病的严重程度与发病年龄之间存在任何相关性。患银屑病且有关节不适的人是未患银屑病且有关节不适的人的两倍，分别为28%和13%。几乎一半（48%）有关节不适的银屑病患者指甲上有银屑病病变。在没有任何Cw6等位基因的人中，9%有内分泌紊乱，但在有Cw6的人中仅为1%。实际上,183名Cw6携带者中无人患糖尿病,而瑞典人群患病率为3 - 5%。
除关节不适外，从患者组织收集的银屑病患者（所研究的）并存疾病的发生率并未增加。
