Appay Victor, Boutboul François, Autran Brigitte
Laboratoire d'Immunologie Cellulaire, Hôpital Pitié-Salpétrière, 47-83 Boulevard de l'Hôpital, 75634 Paris cedex 13, France.
Curr Infect Dis Rep. 2005 Nov;7(6):473-9. doi: 10.1007/s11908-005-0050-9.
Immune activation, a normal immune reaction to pathogens, is now recognized as a major driving force of the CD4 T-cell depletion and immune disorders caused by HIV. By contrast, the natural hosts of its ancestor virus, simian immunodeficiency virus, have adapted to this virus by blocking immune activation and remaining healthy. This review will focus on evidence demonstrating how immune activation associated with HIV infection exhausts immune defenses to HIV as well as the immune system, thus leading to immunosenescence and immunodeficiency, and how treatment can disrupt this vicious and ultimately fatal circle.
