HIV感染中淋巴细胞的更新与概念范式
Turnover of lymphocytes and conceptual paradigms in HIV infection.
作者信息
Silvestri Guido, Feinberg Mark B
机构信息
Emory Vaccine Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA.
出版信息
J Clin Invest. 2003 Sep;112(6):821-4. doi: 10.1172/JCI19799.
Abstract
Prevailing views concerning the pathogenic mechanisms of AIDS have shifted from models that focus primarily on direct HIV-mediated killing of CD4+ T cells to models that emphasize the pathogenic role of generalized immune system activation. The observation that increases in T cell turnover seen in HIV-infected individuals primarily reflect increased proliferation of effector-memory T cells supports the concept that chronic immune activation plays a prominent, if not predominant, role in the pathogenesis of AIDS.
摘要
关于艾滋病致病机制的主流观点已从主要关注HIV直接介导的CD4+T细胞杀伤的模型，转变为强调全身免疫系统激活致病作用的模型。在HIV感染个体中观察到的T细胞周转率增加主要反映了效应记忆T细胞增殖的增加，这一观察结果支持了慢性免疫激活在艾滋病发病机制中发挥显著（即便不是主要）作用的概念。
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