Brasnu Emmanuelle, Wechsler Bertrand, Bron Alain, Charlotte Frederic, Bliefeld Philippe, Lehoang Phuc, Marcelin Anne-Genevieve, Bodaghi Bahram
Department of Ophthalmology, University of Paris VI, Pitie-Salpêtrière Hospital, Paris, France.
Am J Ophthalmol. 2005 Oct;140(4):746-8. doi: 10.1016/j.ajo.2005.04.025.
To report cases of uveitis that are associated with human herpesvirus-8 (HHV-8) and the impact of interferon-alpha therapy on their visual outcome.
Interventional case reports.
Extensive examination was performed in patients with chronic and severe uveitis to exclude a viral cause that requires specific therapy. After histopathologic, molecular, and/or serologic confirmation of HHV-8 uveitis, interferon-alpha2a therapy (3 millions IU/d, 3 days per week, subcutaneously) was initiated.
Two patients of Mediterranean origin were included. HHV-8 serologic result was positive in both cases. Histopathologic examination of conjunctival biopsy specimens confirmed Kaposi's sarcoma in the second case, and quantitative polymerase chain reaction identified HHV-8 DNA in the biopsy specimen. Disease was controlled by interferon-alpha2a in both cases, but maintenance therapy was mandatory to prevent relapses.
HHV-8-associated uveitis is a rare condition in immunocompetent hosts. Severe and chronic conditions may require antiviral and immunomodulatory therapies. Interferon alpha seems to be a good candidate and may be proposed in these cases.
报告与人类疱疹病毒8型（HHV-8）相关的葡萄膜炎病例以及α干扰素治疗对其视力预后的影响。
干预性病例报告。
对慢性重症葡萄膜炎患者进行全面检查，以排除需要特定治疗的病毒病因。在通过组织病理学、分子学和/或血清学确诊HHV-8葡萄膜炎后，开始α干扰素2a治疗（300万国际单位/天，每周3天，皮下注射）。
纳入2例地中海地区患者。2例患者的HHV-8血清学结果均为阳性。第二例患者结膜活检标本的组织病理学检查确诊为卡波西肉瘤，定量聚合酶链反应在活检标本中检测到HHV-8 DNA。2例患者的病情均通过α干扰素2a得到控制，但必须进行维持治疗以预防复发。
HHV-8相关葡萄膜炎在免疫功能正常的宿主中较为罕见。严重和慢性病例可能需要抗病毒和免疫调节治疗。α干扰素似乎是一个不错的选择，可用于这些病例。
