Touitou Valerie, Sene Damien, Fardeau Christine, Boutin Thi-Huong-Du, Duhaut Pierre, Piette Jean-Charles, LeHoang Phuc, Cacoub Patrice, Bodaghi Bahram
Department of Ophthalmology, Pitié-Salpêtrière Hospital, University of Paris VI, 47-83 boulevard de l'Hôpital, 75013 Paris, France.
Int Ophthalmol. 2007 Apr-Jun;27(2-3):211-5. doi: 10.1007/s10792-007-9040-2. Epub 2007 Feb 23.
Successful therapy based on the use of interferon-alpha has been reported in different types of severe chronic uveitis. The immunomodulatory effects of this drug, combined with its antiviral properties seem to contribute to its efficacy in the treatment of different forms of severe and refractory uveitis such as Vogt-Koyanagi-Harada disease, Behçet-associated uveitis, or even human herpes virus 8 (HHV-8) associated uveitis. At the same time, severe ocular complications have been reported in patients treated with interferon-alpha for chronic viral hepatitis C. Among these complications, six cases of Vogt-Koyanagi-Harada-like disease have been described.We report a small case series of two patients with refractory Vogt-Koyanagi-Harada disease, treated with interferon-alpha and discuss the potential benefits or detrimental role of interferon therapy in these patients.
据报道，基于使用α干扰素的成功治疗已应用于不同类型的严重慢性葡萄膜炎。该药物的免疫调节作用及其抗病毒特性似乎有助于其在治疗不同形式的严重和难治性葡萄膜炎（如Vogt-小柳原田病、白塞氏病相关性葡萄膜炎，甚至人类疱疹病毒8型（HHV-8）相关性葡萄膜炎）中的疗效。同时，接受α干扰素治疗慢性丙型病毒性肝炎的患者中已报告出现严重眼部并发症。在这些并发症中，已描述了6例Vogt-小柳原田样疾病。我们报告了一个由两名难治性Vogt-小柳原田病患者组成的小病例系列，他们接受了α干扰素治疗，并讨论了干扰素治疗对这些患者的潜在益处或有害作用。
