Tsalikian Eva, Mauras Nelly, Beck Roy W, Tamborlane William V, Janz Kathleen F, Chase H Peter, Wysocki Tim, Weinzimer Stuart A, Buckingham Bruce A, Kollman Craig, Xing Dongyuan, Ruedy Katrina J
DirectNet Coordinating Center, Jaeb Center for Health Research, Tampa, Florida 33647, USA.
J Pediatr. 2005 Oct;147(4):528-34. doi: 10.1016/j.jpeds.2005.04.065.
To examine the effect of exercise on overnight hypoglycemia in children with type 1 diabetes mellitus (T1DM).
At 5 clinical sites, 50 subjects with T1DM (age 11 to 17 years) were studied in a clinical research center on 2 separate days. One day included an afternoon exercise session on a treadmill. On both days, frequently sampled blood glucose levels were measured at the DirecNet central laboratory. Insulin doses were similar on both days.
During exercise, plasma glucose levels fell in almost all subjects; 11 (22%) developed hypoglycemia. Mean glucose level from 10 pm to 6 am was lower on the exercise day than on the sedentary day (131 vs 154 mg/dL; P=.003). Hypoglycemia developed overnight more often on the exercise nights than on the sedentary nights (P=.009), occurring on the exercise night only in 13 (26%), on the sedentary night only in 3 (6%), on both nights in 11 (22%), and on neither night in 23 (46%). Hypoglycemia was unusual on the sedentary night if the pre-bedtime snack glucose level was>130 mg/dL.
These findings indicate that overnight hypoglycemia after exercise is common in children with T1DM and support the importance of modifying diabetes management after afternoon exercise to reduce the risk of hypoglycemia.
研究运动对1型糖尿病（T1DM）患儿夜间低血糖的影响。
在5个临床地点，50名T1DM患儿（年龄11至17岁）在临床研究中心于2个不同日期接受研究。其中一天包括下午在跑步机上进行的运动。两天均在DirecNet中央实验室测量频繁采样的血糖水平。两天的胰岛素剂量相似。
运动期间，几乎所有受试者的血糖水平均下降；11名（22%）出现低血糖。运动日晚上10点至早上6点的平均血糖水平低于久坐日（131 vs 154 mg/dL；P = 0.003）。运动夜比久坐夜更常出现夜间低血糖（P = 0.009），仅在运动夜出现低血糖的有13名（26%），仅在久坐夜出现的有3名（6%），两晚均出现的有11名（22%），两晚均未出现的有23名（46%）。如果睡前零食血糖水平>130 mg/dL，久坐夜很少出现低血糖。
这些发现表明，运动后夜间低血糖在T1DM患儿中很常见，并支持在下午运动后调整糖尿病管理以降低低血糖风险的重要性。
