Caqueret Aurore, Yang Chun, Duplan Sabine, Boucher Francine, Michaud Jacques L
Research Center, Hôpital Sainte-Justine, Montréal, Canada.
Horm Res. 2005;64(5):222-30. doi: 10.1159/000088977. Epub 2005 Oct 14.
The hypothalamus is a critical integrator of several homeostatic processes that are required for the survival of vertebrates. Disruption of the development of the hypothalamus thus has the potential of perturbing important physiological processes with lifelong consequences. We review current knowledge about how cell types are specified and circuits are formed within the developing hypothalamus. We emphasize the potential clinical impact of the perturbations of these pathways using the regulation of energy balance as a model. We predict that disruption of hypothalamic development is a common, previously unsuspected cause of disorders of homeostatic processes such as obesity and high blood pressure.
下丘脑是脊椎动物生存所需的几种稳态过程的关键整合者。因此，下丘脑发育的破坏有可能扰乱重要的生理过程，并产生终身影响。我们综述了目前关于发育中的下丘脑内细胞类型如何被指定以及神经回路如何形成的知识。我们以能量平衡的调节为模型，强调这些途径扰动的潜在临床影响。我们预测，下丘脑发育的破坏是肥胖和高血压等稳态过程紊乱的一个常见的、以前未被怀疑的原因。
