Pape H, Pöttgen C, Ploem J S, Van Driel-Kulker A M, Wurm R, Schmitt G
Department of Radiotherapy and Radiation Oncology, Heinrich Heine University Düsseldorf, FRG.
Ann Oncol. 1992 Apr;3 Suppl 2:S89-92. doi: 10.1093/annonc/3.suppl_2.s89.
Nuclear DNA content in soft tissue sarcoma was determined by image cytometry using archival, paraffin embedded material. In a retrospective study 138 specimens of 81 patients have been analysed. The ploidy level was correlated to clinical outcome regarding tumor volume and histological grading, the most important prognostic parameters. Ploidy has a significant prognostic value and correlates well with histological grading (p = 0.01). Tumour volume was found to be an independent prognostic factor (p = greater than 0.1) [chi 2 test]. The DNA content of the primary tumour and of multiple local recurrences remained similar.
利用存档的石蜡包埋材料，通过图像细胞术测定软组织肉瘤中的核DNA含量。在一项回顾性研究中，对81例患者的138个标本进行了分析。就肿瘤体积和组织学分级这两个最重要的预后参数而言，倍体水平与临床结果相关。倍体具有显著的预后价值，且与组织学分级密切相关（p = 0.01）。肿瘤体积是一个独立的预后因素（p＞0.1）[卡方检验]。原发肿瘤和多个局部复发灶的DNA含量保持相似。
