美国的β-内酰胺耐药性与肠杆菌科细菌
Beta-lactam resistance and Enterobacteriaceae, United States.
作者信息
Whichard Jean M, Joyce Kevin, Fey Paul D, Nelson Jennifer M, Angulo Frederick J, Barrett Timothy J
机构信息
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
出版信息
Emerg Infect Dis. 2005 Sep;11(9):1464-6. doi: 10.3201/eid1109.050182.
Abstract
Extended-spectrum cephalosporins (ESC) are an important drug class for treating severe Salmonella infections. We screened the human collection from the National Antimicrobial Resistance Monitoring System 2000 for ESC resistance mechanisms. Of non-Typhi Salmonella tested, 3.2% (44/1,378) contained blaCMY genes. Novel findings included blaCMY-positive Escherichia coli O157:H7 and a blaSHV-positive Salmonella isolate. CMY-positive isolates showed a ceftriaxone MIC > or =2 microg/mL.
摘要
超广谱头孢菌素（ESC）是治疗严重沙门氏菌感染的一类重要药物。我们从2000年国家抗菌药物耐药性监测系统的人类样本中筛选了ESC耐药机制。在检测的非伤寒沙门氏菌中，3.2%（44/1378）含有blaCMY基因。新发现包括blaCMY阳性的大肠杆菌O157:H7和一株blaSHV阳性的沙门氏菌分离株。CMY阳性分离株的头孢曲松MIC≥2μg/mL。
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