Said Hakim K, Hijjawi John, Roy Nakshatra, Mogford Jon, Mustoe Thomas
Wound Healing Research Lab, Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, 675 North St. Clair, Chicago, IL 60611, USA.
Arch Surg. 2005 Oct;140(10):998-1004. doi: 10.1001/archsurg.140.10.998.
Transdermal sustained-delivery oxygen therapy improves wound healing.
Experimental study using a well-established rabbit ear model for acute wound healing.
Wound-healing research laboratory in a university center.
Four full-thickness 7-mm punch wounds were created on each ear of young, female New Zealand white rabbits. Treated ears received transdermal sustained delivery of oxygen via silicone tubing tunneled subcutaneously to a pocket under a semiocclusive dressing. Oxygen production (100% oxygen at 3 mL/h continuously) relied on a small, self-contained device connected to the silicone tubing and secured to the rabbit's back for the duration of the experiment using a body harness. Ears were harvested at each of 2 time points: day 5 and day 8.
Histologic analysis of the wounds showed significantly greater healing at both day 5 and day 8 in response to oxygen therapy. Most significantly, epithelial wound coverage was almost doubled in treated ear wounds when compared with controls.
Our results suggest that epithelial wound healing is improved by transdermal sustained-delivery treatment with 100% oxygen.
经皮持续输送氧气疗法可促进伤口愈合。
采用成熟的兔耳急性伤口愈合模型进行实验研究。
大学中心的伤口愈合研究实验室。
在年轻雌性新西兰白兔的每只耳朵上制造4个7毫米的全层打孔伤口。处理过的耳朵通过皮下隧道式硅胶管接受经皮持续氧气输送，硅胶管通向半封闭敷料下的一个囊袋。氧气产生（连续以3毫升/小时的速度输送100%氧气）依靠一个小型独立装置，该装置连接到硅胶管上，并在实验期间使用身体背带固定在兔子背上。在两个时间点（第5天和第8天）分别采集耳朵样本。
伤口的组织学分析显示，在第5天和第8天，氧气疗法均能显著促进愈合。最显著的是，与对照组相比，处理过的耳朵伤口的上皮伤口覆盖率几乎增加了一倍。
我们的结果表明，100%氧气经皮持续输送治疗可促进上皮伤口愈合。
