Ochoa Manuel, Rahimi Rahim, Zhou Jiawei, Jiang Hongjie, Yoon Chang Keun, Maddipatla Dinesh, Narakathu Binu Baby, Jain Vaibhav, Oscai Mark Michael, Morken Thaddeus Joseph, Oliveira Rebeca Hannah, Campana Gonzalo L, Cummings Oscar W, Zieger Michael A, Sood Rajiv, Atashbar Massood Z, Ziaie Babak
School of Electrical and Computer Engineering, Purdue University, West Lafayette, 47907 IN USA.
Birck Nanotechnololgy Center, 1205W State Street, West Lafayette, 47907 IN USA.
Microsyst Nanoeng. 2020 May 18;6:46. doi: 10.1038/s41378-020-0141-7. eCollection 2020.
Chronic wounds affect over 6.5 million Americans and are notoriously difficult to treat. Suboptimal oxygenation of the wound bed is one of the most critical and treatable wound management factors, but existing oxygenation systems do not enable concurrent measurement and delivery of oxygen in a convenient wearable platform. Thus, we developed a low-cost alternative for continuous O delivery and sensing comprising of an inexpensive, paper-based, biocompatible, flexible platform for locally generating and measuring oxygen in a wound region. The platform takes advantage of recent developments in the fabrication of flexible microsystems including the incorporation of paper as a substrate and the use of a scalable manufacturing technology, inkjet printing. Here, we demonstrate the functionality of the oxygenation patch, capable of increasing oxygen concentration in a gel substrate by 13% (5 ppm) in 1 h. The platform is able to sense oxygen in a range of 5-26 ppm. In vivo studies demonstrate the biocompatibility of the patch and its ability to double or triple the oxygen level in the wound bed to clinically relevant levels.
慢性伤口影响着超过650万美国人，而且 notoriously难以治疗。伤口床的氧合不足是伤口管理中最关键且可治疗的因素之一，但现有的氧合系统无法在便捷的可穿戴平台上同时进行氧气的测量和输送。因此，我们开发了一种低成本的连续氧气输送和传感替代方案，它由一个廉价的、基于纸张的、生物相容的、灵活的平台组成，用于在伤口区域局部生成和测量氧气。该平台利用了柔性微系统制造方面的最新进展，包括将纸张用作基底以及使用可扩展制造技术——喷墨打印。在此，我们展示了氧合贴片的功能，它能够在1小时内使凝胶基质中的氧气浓度增加13%（5 ppm）。该平台能够在5 - 26 ppm的范围内检测氧气。体内研究证明了贴片的生物相容性以及它将伤口床中的氧气水平提高两倍或三倍至临床相关水平的能力。
