系统性红斑狼疮患者血清中III型前胶原氨基端前肽和I型前胶原前肽的浓度

Serum concentrations of aminoterminal propeptide of type III procollagen and propeptide of human type I procollagen in systemic lupus erythematosus.

作者信息

Villa-Manzano A I, Gamez-Nava J I, Salazar-Paramo M, Valera-Gonzalez I C, Garcia-Gonzalez A, Garcia-Gonzalez G, Morales-Romero J, Lopez-Olivo A, Galvan-Ramirez L M, Ruiz-Ruvalcaba R, Cardona-Muñoz E G, Gonzalez-Lopez L

机构信息

Division of Musculoskeletal, Autoinmune and Metabolic Diseases, Clinical Epidemiology Research Unit, Hospital de Especialidades del Centro Medico Nacional de Occidente, IMSS, Guadalajara, Jalisco, México, and Baylor College of Medicine, Houston, TX, USA.

出版信息

Rheumatol Int. 2006 Jun;26(8):712-6. doi: 10.1007/s00296-005-0064-5. Epub 2005 Oct 18.

DOI:10.1007/s00296-005-0064-5

PMID:16231121

Abstract

The purpose of this study was to assess the association between the serum levels of aminoterminal propeptide of type III procollagen (PIIINP) and carboxyterminal propeptide of type I procollagen (PICP) with disease activity and damage in systemic lupus erythematosus (SLE). Thirty-three patients with SLE were compared with 31 controls. The assessment in SLE included disease activity indices (SLEDAI, MEX-SLEDAI) and damage index (SLICC/ACR). PIIINP and PICP were measured by radioimmunoassay. Compared with controls, mean levels of PIIINP were higher in SLE (2.9+/-1.8 vs. 1.8+/-1.2, P=0.006). PICP was also increased in SLE versus controls (163+/-94 vs. 102+/-62, P=0.007). PIIINP was correlated with SLICC/ACR (r=0.33, P=0.048). No correlation was observed between PICP and PIIINP with other clinical or therapeutic variables. These preliminary data suggests a role of PIIINP as a marker for chronic damage. Follow-up studies are required to evaluate its utility in predicting future damage.

摘要

本研究旨在评估系统性红斑狼疮（SLE）患者血清III型前胶原氨基端前肽（PIIINP）和I型前胶原羧基端前肽（PICP）水平与疾病活动度及损伤之间的关联。将33例SLE患者与31例对照进行比较。对SLE患者的评估包括疾病活动指数（SLEDAI、MEX - SLEDAI）和损伤指数（SLICC/ACR）。采用放射免疫分析法测定PIIINP和PICP。与对照组相比，SLE患者的PIIINP平均水平更高（2.9±1.8 vs. 1.8±1.2，P = 0.006）。与对照组相比，SLE患者的PICP水平也升高（163±94 vs. 102±62，P = 0.007）。PIIINP与SLICC/ACR相关（r = 0.33，P = 0.048）。未观察到PICP和PIIINP与其他临床或治疗变量之间存在相关性。这些初步数据表明PIIINP可作为慢性损伤的标志物。需要进行随访研究以评估其在预测未来损伤方面的效用。