McLellan D S, Jurd K M
School of Pharmacy and Biomedical Sciences, Portsmouth Polytechnic, UK.
Blood Coagul Fibrinolysis. 1992 Feb;3(1):69-77. doi: 10.1097/00001721-199202000-00011.
Anticoagulant properties were first described in extracts from marine algae over 50 years ago. Currently over 60 species, representing the three major divisions of marine algae, have been reported to have such properties. The major active components are a variety of sulphated polysaccharides, some of which characterize as proteoglycans. These sulphated polysaccharides/proteoglycans exert antithrombin properties, primarily mediated by heparin cofactor II (HCII). However antithrombin III (ATIII) mediated anticoagulant activities, as well as an element of direct antithrombin activity, have also been observed.
50多年前，人们首次在海藻提取物中发现了抗凝特性。目前，据报道，代表海藻三大类别的60多种海藻具有这样的特性。主要活性成分是多种硫酸化多糖，其中一些属于蛋白聚糖。这些硫酸化多糖/蛋白聚糖具有抗凝血酶特性，主要由肝素辅因子II（HCII）介导。然而，也观察到了抗凝血酶III（ATIII）介导的抗凝活性以及直接抗凝血酶活性的成分。
