UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Curr Med Chem. 2017;24(2):149-175. doi: 10.2174/0929867323666161028160416.
Polysaccharides are abundant components in marine macroalgae with potential applications in different areas such as pharmaceutical, biomedical, cosmetics and nutrition. The current interest in these compounds is due to their known bioactivities, conferred by their antiallergic, neuroprotective, gastroprotective, cardioprotective, cytotoxic, anticoagulant/antithrombotic, antiviral, antilipidemic, antinociceptive, and immunomodulatory properties, making them promising bioactive products and biomaterials. The inflammatory process is a complex event mediated by the immune system that culminates in the neutralization and elimination of the offending insult protecting the host and restoring tissue homeostasis. This review focuses on the extraction procedures and chemical characterization of polysaccharides from different classes of algae (Phaeophyceae, Rhodophyceae and Chlorophyceae) and on the studies on their inflammatory process modulatory effect.
多糖是海洋大型藻类中的丰富成分,具有在医药、生物医学、化妆品和营养等不同领域应用的潜力。目前人们对这些化合物的兴趣源于其已知的生物活性,这些活性由其抗过敏、神经保护、胃保护、心脏保护、细胞毒性、抗凝/抗血栓形成、抗病毒、降血脂、镇痛、免疫调节特性赋予,使它们成为有前途的生物活性产品和生物材料。炎症过程是一个由免疫系统介导的复杂事件,其最终结果是中和和消除侵害,从而保护宿主并恢复组织内稳态。本综述重点介绍了不同类别的藻类(褐藻、红藻和绿藻)中多糖的提取程序和化学特性,以及它们对炎症过程调节作用的研究。