Hoes M J
Acta Psychiatr Belg. 1979 Nov-Dec;79(6):638-46.
This study investigations whether the synthesis of nicotinamide out of L-tryptophan is disordered in depression or in anxiety. To this end the excretion of xanthurenic acid (XA) in 24 hours urine was measured after administration of an oral loading dose of 5 grams L-tryptophan. The subjects were depressive, anxious, and alcoholic patients, while other psychiatric patients, served as control group. Anxiety and not depression is the clinical correlate of an elevated excretion of XA. Liver disorder and vitamin B-6 deficiency have to be excluded. A psychiatric control group is necessary.
本研究调查了抑郁症或焦虑症患者中，由L-色氨酸合成烟酰胺的过程是否紊乱。为此，在口服5克L-色氨酸负荷剂量后，测量24小时尿液中黄尿酸（XA）的排泄量。受试者包括抑郁症患者、焦虑症患者和酒精性患者，其他精神疾病患者作为对照组。XA排泄量升高的临床相关因素是焦虑而非抑郁。必须排除肝脏疾病和维生素B-6缺乏症。需要一个精神疾病对照组。
