Maes M, De Ruyter M, Suy E
Acta Psychiatr Belg. 1986 Mar-Apr;86(2):120-30.
The xanthurenic acid (XA) flow in 24-hour urine following L-tryptophan loading was determined in a control group and in depressive patients divided into two DSM-III categories: minor depression (dysthymic disorder, atypical depression, adaptation disorder with depressive mood), and major depression. The XA flow is not significantly (p = 0.15) different in these categories of depression and in the control group. The number of patients with an abnormal XA flow (cut-off value greater than or equal to 106.8 mu mol/24 hours) is not significantly different among these groups (p = 0.40). The XA flow is therefore not relevant whether for depression or major depression. The XA flow in 24-hour urine following L-tryptophan loading decreases with age (p = 0.006) and increases with the 24-hour urinary output (p = 0.02). Women excrete significantly more XA (p = 0.02) than men. One must take age, 24-hour urinary output and sex into account for the interpretation of the XA data.
在对照组以及被分为两个DSM-III类别的抑郁症患者（轻度抑郁症，即恶劣心境障碍、非典型抑郁症、伴抑郁情绪的适应障碍，和重度抑郁症）中，测定了L-色氨酸负荷后24小时尿中的黄尿酸（XA）流量。在这些抑郁症类别和对照组中，XA流量没有显著差异（p = 0.15）。XA流量异常（临界值大于或等于106.8 μmol/24小时）的患者数量在这些组之间没有显著差异（p = 0.40）。因此，XA流量无论是对于抑郁症还是重度抑郁症都没有相关性。L-色氨酸负荷后24小时尿中的XA流量随年龄下降（p = 0.006），并随24小时尿量增加（p = 0.02）。女性排泄的XA显著多于男性（p = 0.02）。在解释XA数据时，必须考虑年龄、24小时尿量和性别。
