Darlington C L, Smith P F
Department of Psychology, Neuroscience Research Centre, University of Otago, Dunedin, New Zealand.
Neuroreport. 1992 Feb;3(2):143-5. doi: 10.1097/00001756-199202000-00005.
A single injection of the Ca2+ channel antagonist verapamil (0.4 or 0.8 mg kg-1, i.m.) was given to adult guinea-pigs 1 h before a unilateral labyrinthectomy and the effects on the compensation of spontaneous ocular nystagmus (SN) were measured. At the 0.8 mg kg-1 dose, pre-treatment with verapamil significantly reduced SN frequency compared to saline controls; however, it also reduced the rate of SN compensation, resulting in no significant difference in the time required to reach maximal compensation. These results suggest the possibility that voltage-dependent Ca2+ channels may be involved in vestibular compensation.
在成年豚鼠单侧迷路切除术前1小时，单次注射钙通道拮抗剂维拉帕米（0.4或0.8mg/kg，肌肉注射），并测量其对自发性眼球震颤（SN）代偿的影响。在0.8mg/kg剂量下，与生理盐水对照组相比，维拉帕米预处理显著降低了SN频率；然而，它也降低了SN代偿的速率，导致达到最大代偿所需的时间没有显著差异。这些结果提示电压依赖性钙通道可能参与前庭代偿。
