Martin J, Gilchrist D P, Smith P F, Darlington C L
Department of Psychology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand.
J Vestib Res. 1996 Mar-Apr;6(2):135-9.
Diazepam and other benzodiazepines are sometimes used to alleviate vertigo and dizziness following labyrinthine surgery in humans. While the results of some previous studies have suggested that the administration of diazepam and other CNS depressant drugs following unilateral labyrinthectomy (UL) may impair the vestibular compensation process, the available evidence is unclear. The objective of the present experiment was to examine the effects of multiple injections of a high dose of diazepam (that is, 10 mg/kg i.p.) 30 min before and following UL (10 h or 10 and 20 h) on the static symptom, spontaneous ocular nystagmus (SN), in guinea pigs. Although diazepam-treated animals exhibited consistently lower average SN frequency compared to vehicle controls. neither SN frequency nor its rate of compensation were significantly different between the 2 groups. The time to complete SN compensation was also similar for the 2 groups, as estimated from the x intercepts derived from a linear regression analysis. These results suggest that even high doses of diazepam before and following UL do not result in an impairment of compensation of SN in guinea pig.
地西泮和其他苯二氮䓬类药物有时用于缓解人类迷宫手术后的眩晕和头晕。虽然之前一些研究的结果表明，单侧迷路切除术后（UL）给予地西泮和其他中枢神经系统抑制药物可能会损害前庭代偿过程，但现有证据并不明确。本实验的目的是研究在豚鼠进行UL手术前30分钟以及术后（10小时或10和20小时）多次注射高剂量地西泮（即10毫克/千克腹腔注射）对静态症状、自发性眼球震颤（SN）的影响。尽管与溶剂对照组相比，接受地西泮治疗的动物平均SN频率始终较低，但两组之间的SN频率及其代偿率均无显著差异。根据线性回归分析得出的x截距估计，两组完成SN代偿的时间也相似。这些结果表明，即使在UL手术前后给予高剂量地西泮，也不会导致豚鼠SN代偿受损。
