Gilchrist D P, Smith P F, Darlington C L
Department of Psychology, University of Otago, Dunedin, New Zealand.
Neurosci Lett. 1990 Oct 2;118(1):14-6. doi: 10.1016/0304-3940(90)90237-4.
Neuropeptide hormones such as adrenocorticotropic hormone, fragment 4-10 (ACTH(4-10], have been shown to facilitate various kinds of CNS plasticity, including recovery from deafferentation of the inner ear (vestibular compensation). The purpose of the present experiment was to determine whether the rapid compensation of spontaneous nystagmus (SN), which occurs over 2-3 days post-unilateral labyrinthectomy (UL) in the guinea pig, could be accelerated by administration of ACTH(4-10). Because of the short half-life of ACTH(4-10), injections of 200 micrograms/kg i.m. were given every 4 h for 48 h post-UL, and SN was measured every 2 h for 52 h post-UL. The results were compared with SN measurements from guinea pigs which received saline injections of the same volume, at the same times. ACTH(4-10) injections were found to significantly accelerate the rate of compensation of SN following UL. This result suggests that ACTH(4-10) may be useful in facilitating compensation when the symptoms of UL are most severe, during the first 2-3 days post-UL.
诸如促肾上腺皮质激素4 - 10片段（ACTH(4 - 10)）之类的神经肽激素已被证明可促进各种中枢神经系统可塑性，包括从内耳去传入（前庭代偿）中恢复。本实验的目的是确定在豚鼠单侧迷路切除术后2 - 3天内发生的自发性眼球震颤（SN）的快速代偿是否可通过给予ACTH(4 - 10)来加速。由于ACTH(4 - 10)的半衰期短，在单侧迷路切除术后48小时内每4小时肌肉注射200微克/千克，并在单侧迷路切除术后52小时内每2小时测量一次SN。将结果与在相同时间接受相同体积盐水注射的豚鼠的SN测量结果进行比较。发现注射ACTH(4 - 10)可显著加速单侧迷路切除术后SN的代偿速度。该结果表明，在单侧迷路切除术后的头2 - 3天，当单侧迷路切除术后症状最严重时，ACTH(4 - 10)可能有助于促进代偿。
