Kaneko Y, Frizzera G, Shikano T, Kobayashi H, Maseki N, Sakurai M
Department of Laboratory Medicine, Saitama Cancer Center, Japan.
Leukemia. 1989 Dec;3(12):886-92.
In this study of 33 T cell acute lymphoblastic leukemia (T ALL) and 17 lymphoblastic lymphoma (LBL) patients, no relevant differences between the two groups were observed in clinical characteristics, response to therapy, and survival. We found translocations involving 14q11, 7q35, or 7p15, where T cell receptor alpha and delta, beta, and gamma subunit genes reside, in 20 patients (40%). Most of these translocations were seen with equal frequency in T ALL and LBL, indicating that, in a large proportion, the two diseases are different manifestations of the same lymphoblastic disorder. However, other translocations, such as t(9;17)(q34;q23), occurred only in LBL, perhaps pointing to the existence of subsets of LBLs that are distinct from T ALL. On the basis of karyotype, 50 patients could be classified into three groups: 20 patients with 14q11, 7q35, or 7p15 translocations (group A); 20 with other translocations, and/or deletions (group B); and 10 with normal diploidy (group C). There was no difference in survival time between any two of the three groups.
在这项针对33例T细胞急性淋巴细胞白血病（T ALL）患者和17例淋巴细胞淋巴瘤（LBL）患者的研究中，两组患者在临床特征、治疗反应和生存率方面未观察到相关差异。我们在20例患者（40%）中发现了涉及14q11、7q35或7p15的易位，T细胞受体α和δ、β以及γ亚基基因位于这些区域。这些易位在T ALL和LBL中出现的频率大致相同，这表明在很大程度上，这两种疾病是同一淋巴细胞疾病的不同表现形式。然而，其他易位，如t(9;17)(q34;q23)，仅在LBL中出现，这可能表明存在与T ALL不同的LBL亚群。根据核型，50例患者可分为三组：20例有14q11、7q35或7p15易位的患者（A组）；20例有其他易位和/或缺失的患者（B组）；10例核型正常的患者（C组）。三组中任意两组之间的生存时间均无差异。
