蛋白结合型同型半胱氨酸。冠状动脉疾病的一个可能危险因素。
Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease.
作者信息
Kang S S, Wong P W, Cook H Y, Norusis M, Messer J V
出版信息
J Clin Invest. 1986 May;77(5):1482-6. doi: 10.1172/JCI112461.
The development of atherosclerotic changes and thromboembolism are common features in homocystinurics. Hence, we postulate a positive correlation between the level of homocyst(e)ine in the blood and the occurrence of coronary artery disease. Homocysteine is found either as free homocystine, cysteine-homocysteine mixed disulfide, or protein-bound homocyst(e)ine. In nonhomocystinuric subjects, most homocysteine molecules are detectable in the protein-bound form. Thus, protein-bound homocyst(e)ine in stored plasma which reflected total plasma homocyst(e)ine was determined in 241 patients with coronary artery disease (173 males and 68 females). The mean +/- SD total plasma homocyst(e)ine was 5.41 +/- 1.62 nmol/ml in male patients, 4.37 +/- 1.09 nmol/ml in male controls, 5.66 +/- 1.93 nmol/ml in female patients, and 4.16 +/- 1.62 nmol/ml in female controls. The differences between the patients with coronary artery disease and the controls were statistically significant (P less than 0.0005).
动脉粥样硬化改变和血栓栓塞的发展是高胱氨酸尿症患者的常见特征。因此，我们推测血液中同型半胱氨酸水平与冠状动脉疾病的发生之间存在正相关。同型半胱氨酸以游离同型胱氨酸、半胱氨酸-同型半胱氨酸混合二硫化物或蛋白质结合型同型半胱氨酸的形式存在。在非高胱氨酸尿症患者中，大多数同型半胱氨酸分子以蛋白质结合形式可检测到。因此，我们测定了241例冠状动脉疾病患者（173例男性和68例女性）储存血浆中反映总血浆同型半胱氨酸的蛋白质结合型同型半胱氨酸。男性患者血浆总同型半胱氨酸的平均值±标准差为5.41±1.62 nmol/ml，男性对照组为4.37±1.09 nmol/ml，女性患者为5.66±1.93 nmol/ml，女性对照组为4.16±1.62 nmol/ml。冠状动脉疾病患者与对照组之间的差异具有统计学意义（P＜0.0005）。
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