Thomas Gareth O, Wilkinson Matthew, Hodson Susan, Jones Kevin C
Department of Environmental Sciences, IENS, Lancaster University, Lancaster LA1 4YQ, UK.
Environ Pollut. 2006 May;141(1):30-41. doi: 10.1016/j.envpol.2005.08.027. Epub 2005 Oct 19.
Blood serum from 154 volunteers at 13 UK locations in 2003 were analysed for a range of PCBs, organochlorine pesticides and PBDEs. HCB, p,p'-DDE and p,p'-DDT and beta-HCH were the dominant organochlorine pesticides in most samples. BDEs 47, 99, 100, 153, 154 and 183 were the most regularly detected PBDEs. This study is the first report of BDE209 in UK human blood (found in 11 samples, range < 15-240 ng/g lipid). Concentration and age correlated for the less easily metabolised PCBs, p,p'-DDT and p,p'-DDE, HCB and HCHs. With increasing age females tended to have lower concentrations of the more chlorinated PCBs than males. Similar PBDE concentrations, and distributions, to those reported in the general population in Sweden in 2002 were found, despite differences in historical PBDE production and usage. There is increasing regulation to control persistent and bioaccumulative chemicals, and establishing human exposure will help to identify substances which should be urgently phased out.
2003年，对来自英国13个地点的154名志愿者的血清进行了分析，检测了一系列多氯联苯（PCBs）、有机氯农药和多溴二苯醚（PBDEs）。六氯苯（HCB）、p,p'-滴滴伊（p,p'-DDE）、p,p'-滴滴涕（p,p'-DDT）和β-六氯环己烷（β-HCH）是大多数样本中主要的有机氯农药。BDE-47、99、100、153、154和183是最常检测到的多溴二苯醚。本研究首次报道了英国人体血液中的BDE209（在11个样本中发现，范围<15 - 240 ng/g脂质）。对于较难代谢的多氯联苯、p,p'-DDT、p,p'-DDE、HCB和六氯环己烷，浓度与年龄相关。随着年龄的增长，女性体内氯化程度较高的多氯联苯浓度往往低于男性。尽管多溴二苯醚的历史生产和使用情况存在差异，但发现其浓度和分布与2002年瑞典普通人群报告的情况相似。对持久性和生物累积性化学品的管控日益严格，确定人体接触情况将有助于识别应紧急淘汰的物质。
