Division of Environmental Science and Engineering|, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Pohang, 37673, Republic of Korea.
Division of Polar Paleoenvironment, Korea Polar Research Institute (KOPRI), 26 Songdomirae-ro, Incheon, 21990, Republic of Korea.
Environ Sci Pollut Res Int. 2018 Jan;25(1):249-259. doi: 10.1007/s11356-017-0382-7. Epub 2017 Oct 14.
The serum levels of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) were measured in a middle-aged Korean population and investigated associations with age, gender, body mass index (BMI), metabolic syndrome (MS), type 2 diabetes mellitus (T2DM), and dietary habits. The median concentrations of 22 OCPs and 34 PCBs in the serum samples were 483 and 216 ng g lipid, respectively. The most abundant compound was p,p'-DDE, followed by PCB 153, β-HCH, PCB 118, and PCB 180. The results of multiple linear regression and other statistical analyses revealed that serum OCP and PCB levels were higher in women and were positively correlated with age. BMI was positively associated with serum OCP and PCB levels, reflecting the influence of food intake and the preserving effect of body fat. MS and T2DM were significantly associated with serum OCP and PCB levels. The intake of animal foods had positive associations with serum OCP and PCB levels, whereas the intake of phytogenic foods showed negative associations, presumably because of contamination levels in food items and food matrices that governs absorption and excretion of OCPs and PCBs in the body. The relationship between dietary habits and serum OCP and PCB levels were different in participants with MS compared to healthy participants, suggesting MS may alter the influence of food intake on serum OCP and PCB levels.
血清有机氯农药（OCPs）和多氯联苯（PCBs）水平在中年韩国人群中进行了测量，并研究了它们与年龄、性别、体重指数（BMI）、代谢综合征（MS）、2 型糖尿病（T2DM）和饮食习惯的关系。血清样本中 22 种 OCP 和 34 种 PCB 的中位数浓度分别为 483 和 216ng/g 脂质。最丰富的化合物是 p,p'-DDE，其次是 PCB 153、β-HCH、PCB 118 和 PCB 180。多元线性回归和其他统计分析的结果表明，女性血清 OCP 和 PCB 水平较高，且与年龄呈正相关。BMI 与血清 OCP 和 PCB 水平呈正相关，反映了食物摄入和体脂肪的保存效应的影响。MS 和 T2DM 与血清 OCP 和 PCB 水平显著相关。动物食品的摄入与血清 OCP 和 PCB 水平呈正相关，而植物性食品的摄入则呈负相关，这可能是由于食物和食物基质中的污染水平控制了 OCPs 和 PCBs 在体内的吸收和排泄。与健康参与者相比，MS 患者的饮食习惯与血清 OCP 和 PCB 水平之间的关系不同，这表明 MS 可能改变了食物摄入对血清 OCP 和 PCB 水平的影响。
