通过一锅三步缩合反应合成新型 4H-嘧啶并[1,6-a]嘧啶。
Synthesis of novel 4H-pyrimido[1,6-a]pyrimidines via a one-pot three-component condensation.
机构信息
The Center for Combinatorial Chemistry and Drug Discovery, The School of Pharmaceutical Sciences and The College of Chemistry, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, People's Republic of China.
出版信息
Mol Divers. 2012 Feb;16(1):173-81. doi: 10.1007/s11030-011-9345-y. Epub 2011 Dec 4.
Highly substituted novel 4H-pyrimido[1,6-a] pyrimidines were prepared by a trifluoromethanesulfonic acid catalyzed one-pot three-component condensation of 4-aminopyrimidines, aldehydes, and β-ketoesters. A preliminary feasibility study was undertaken on these compounds, to assess the potential production of a library of further diversified compounds by nucleophilic replacement of Cl(R(1)) or by reaction of electrophiles with the NH(2)(R(2)) group.
高取代新型 4H-嘧啶并[1,6-a]嘧啶通过三氟甲磺酸催化的 4-氨基嘧啶、醛和β-酮酯的一锅法三组分缩合反应制备。对这些化合物进行了初步的可行性研究，以评估通过亲核取代 Cl(R(1))或通过与 NH(2)(R(2))基团的反应来进一步多样化化合物库的潜在生产。
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