Chen Yue, Rennie Donna, Cormier Yvon, Dosman James
Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, ON, Canada K1H 8M5.
Chest. 2005 Oct;128(4):3048-54. doi: 10.1378/chest.128.4.3048.
To investigate the possibility of sex specificity for the association of obesity and asthma using objective measures of body mass index (BMI) and waist circumference (WC).
Cross-sectional study of adults (n = 2,057) living in Humboldt, SK, Canada in 2003.
A rural community.
Ever-asthma was defined as lifetime physician-diagnosed asthma, and recent asthma was defined as asthma diagnosed by a physician during the past 12 months. BMI and WC were objectively measured.
Among the participants, 5.6% of men and 10.0% of women reported having ever-asthma, and 2.7% and 6.0% had recent asthma, respectively. Higher levels of both BMI and WC were significantly associated with asthma in women but not in men. The adjusted odds ratios for women with a BMI of at least 30.0 kg/m2 relative to women with a BMI of < 25.0 kg/m2 were 2.06 (95% confidence interval [CI], 1.42 to 4.05) for ever-asthma and 3.47 (95% CI, 1.64 to 7.32) for recent asthma.
Our study demonstrated that the increased risk of asthma associated with obesity was only significant in women but not in men even when BMI was objectively measured, and this association was robust to the anthropometric measures.
使用体重指数（BMI）和腰围（WC）的客观测量指标，调查肥胖与哮喘之间关联的性别特异性可能性。
2003年对居住在加拿大萨斯喀彻温省洪堡市的成年人（n = 2057）进行的横断面研究。
一个农村社区。
曾患哮喘定义为终生经医生诊断的哮喘，近期哮喘定义为过去12个月内经医生诊断的哮喘。客观测量BMI和WC。
在参与者中，5.6%的男性和10.0%的女性报告曾患哮喘，近期哮喘的患病率分别为2.7%和6.0%。BMI和WC水平较高与女性哮喘显著相关，但与男性无关。BMI至少为30.0 kg/m²的女性相对于BMI<25.0 kg/m²的女性，曾患哮喘的调整比值比为2.06（95%置信区间[CI]，1.42至4.05），近期哮喘的调整比值比为3.47（95%CI，1.64至7.32）。
我们的研究表明，即使客观测量BMI，肥胖与哮喘相关的风险增加仅在女性中显著，在男性中不显著，并且这种关联在人体测量指标方面是稳健的。
