Arvidsson Daniel, Slinde Frode, Nordenson Anita, Larsson Sven, Hulthén Lena
Department of Clinical Nutrition, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
Clin Nutr. 2006 Feb;25(1):68-74. doi: 10.1016/j.clnu.2005.09.001. Epub 2005 Oct 18.
BACKGROUND & AIMS: Malnutrition and weight loss are common in patients with chronic obstructive pulmonary disease (COPD) and effective nutritional support relies on accurate assessment of energy requirement. This could only be performed by measuring energy expenditure using objective methods. The aim of this study was to examine the validity of the ActiReg system in assessing energy requirement in non-hospitalized patients with severe COPD, using doubly labelled water (DLW) as criterion method.
Total energy expenditure (TEE) was assessed from 14 days DLW analysis in 13 patients. During the first 7 days TEE was simultaneously assessed using the ActiReg system, combining measured resting energy expenditure (REE) with physical activity monitoring.
A difference of -88 (782) kJ d(-1) (P = 0.69) was observed between the ActiReg system and DLW. REE explained 52% of the variation in TEE from DLW. Adding physical activity energy expenditure from the ActiReg system (PAEE(AR) = TEE(AR)-REE) increased the explained variation in TEE from DLW with 16%.
The ActiReg system is valid in assessing energy requirement in non-hospitalized patients with severe COPD. The unique feature of being able to discriminate within both the low intensity activity range and moderate-to-high intensity activity range makes the ActiReg system a valuable tool in clinical nutritional support.
营养不良和体重减轻在慢性阻塞性肺疾病（COPD）患者中很常见，有效的营养支持依赖于对能量需求的准确评估。这只能通过使用客观方法测量能量消耗来实现。本研究的目的是使用双标记水（DLW）作为标准方法，检验ActiReg系统在评估非住院重度COPD患者能量需求方面的有效性。
通过对13例患者进行14天的DLW分析来评估总能量消耗（TEE）。在头7天内，同时使用ActiReg系统评估TEE，该系统将测量的静息能量消耗（REE）与身体活动监测相结合。
ActiReg系统与DLW之间观察到的差异为 -88（782）kJ d⁻¹（P = 0.69）。REE解释了DLW测量的TEE变化的52%。加入ActiReg系统的身体活动能量消耗（PAEE(AR) = TEE(AR) - REE）使DLW测量的TEE的解释变异增加了16%。
ActiReg系统在评估非住院重度COPD患者的能量需求方面是有效的。能够在低强度活动范围和中高强度活动范围内进行区分这一独特特性，使ActiReg系统成为临床营养支持中的一个有价值的工具。
