65 岁及以上成年人使用双标水测量的总能量消耗：国际数据可用性和数据共享机会。
Total energy expenditure in adults aged 65 years and over measured using doubly-labelled water: international data availability and opportunities for data sharing.
机构信息
Department of Nutrition, Dietetics & Food, Monash University, Level 1, 264 Ferntree Gully Road, Notting Hill, VIC, 3168, Australia.
Allied Health Clinical Research Office, Eastern Health, 5 Arnold Street, 3128, Box Hill, VIC, Australia.
出版信息
Nutr J. 2018 Mar 26;17(1):40. doi: 10.1186/s12937-018-0348-8.
BACKGROUND
Increasing population lifespan necessitates a greater understanding of nutritional needs in older adults (65 year and over). A synthesis of total energy expenditure in the older population has not been undertaken and is needed to inform nutritional requirements. We aimed to establish the extent of the international evidence for total energy expenditure (TEE) using doubly-labelled water (DLW) in older adults (65 years and over), report challenges in obtaining primary data, and make recommendations for future data sharing.
METHODS
Four databases were searched to identify eligible studies; original research of any study design where participant level TEE was measured using DLW in participants aged ≥65 years. Once studies were identified for inclusion, authors were contacted where data were not publicly available.
RESULTS
Screening was undertaken of 1223 records; the review of 317 full text papers excluded 170 records. Corresponding or first authors of 147 eligible studies were contacted electronically. Participant level data were publicly available or provided by authors for 45 publications (890 participants aged ≥65 years, with 248 aged ≥80 years). Sixty-seven percent of the DLW data in this population were unavailable due to authors unable to be contacted or declining to participate, or data being irretrievable.
CONCLUSIONS
The lack of data access limits the value of the original research and its contribution to nutrition science. Openly accessible DLW data available through publications or a new international data repository would facilitate greater integration of current research with previous findings and ensure evidence is available to support the needs of the ageing population.
TRIAL REGISTRATION
The protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42016047549 .
背景
人口寿命的延长需要我们更深入地了解老年人（65 岁及以上）的营养需求。目前尚未对老年人的总能量消耗进行综合分析，而这对于明确营养需求至关重要。本研究旨在评估使用双标水（DLW）测量老年人（65 岁及以上）总能量消耗的国际证据，并报告获取原始数据所面临的挑战，同时为未来的数据共享提出建议。
方法
我们在四个数据库中检索了符合条件的研究；原始研究设计为任何研究设计，参与者水平的 TEE 使用 DLW 进行测量，参与者年龄≥65 岁。一旦确定了符合纳入标准的研究，我们就会联系作者，以获取未公开的数据。
结果
经过筛选，共纳入 1223 篇记录；对 317 篇全文论文的评估排除了 170 篇记录。共联系了 147 篇合格研究的相应或第一作者。45 篇出版物（890 名年龄≥65 岁的参与者，其中 248 名年龄≥80 岁）的参与者水平数据是公开的或由作者提供的。由于作者无法联系或拒绝参与，或数据无法检索，该人群中 67%的 DLW 数据无法获得。
结论
数据获取的限制限制了原始研究的价值及其对营养科学的贡献。通过出版物或新的国际数据存储库提供公开可获取的 DLW 数据，将有助于将当前研究与以往发现更紧密地结合起来，并确保有证据支持老龄化人口的需求。
试验注册
该方案在国际前瞻性系统评价登记处（PROSPERO）进行了注册，注册编号为 CRD42016047549 。
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