Bass Brenda L, Hellwig Sabine, Hundley Heather A
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, Salt Lake City 84132, USA.
Cell. 2005 Oct 21;123(2):181-3. doi: 10.1016/j.cell.2005.10.009.
In this issue of Cell, Prasanth et al. (2005) provide evidence that an inosine-containing RNA that is normally retained in the nucleus is cleaved within its 3' untranslated region following cellular stress. It is then transported to the cytoplasm and translated into protein. These findings suggest that the nucleus may store RNAs destined for translation that then can be released, as needed, in response to specific cellular signals.
在本期《细胞》杂志中,普拉萨恩特等人(2005年)提供了证据,表明一种正常情况下保留在细胞核中的含次黄苷RNA在细胞应激后于其3'非翻译区被切割。然后它被转运到细胞质中并翻译成蛋白质。这些发现表明,细胞核可能储存着 destined for translation的RNA,然后可根据需要响应特定的细胞信号而释放。 (注:这里“destined for translation”直译为“注定用于翻译”,结合语境意译为“有待翻译”更通顺) 完整译文:在本期《细胞》杂志中,普拉萨恩特等人(2005年)提供了证据,表明一种正常情况下保留在细胞核中的含次黄苷RNA在细胞应激后于其3'非翻译区被切割。然后它被转运到细胞质中并翻译成蛋白质。这些发现表明,细胞核可能储存着有待翻译的RNA,然后可根据需要响应特定的细胞信号而释放。