健康受试者中甲基硫酸地非那明的药代动力学
Pharmacokinetics of diphemanil methylsulphate in healthy subjects.
作者信息
Vidal A M, Rey E, Pons G, Pello J Y, d'Athis P, Olive G
机构信息
Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Paris, France.
出版信息
Eur J Clin Pharmacol. 1992;42(6):689-91. doi: 10.1007/BF00265939.
PMID:1623915
Abstract
The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (tmax = 2 to 4 h), the mean half-life was 8.35 h, and the amount of the drug recovered in urine within 48 h ranged from 0.6 to 7.4% of the administered dose. The results suggest low bioavailability, assuming that the drug is poorly metabolized.
摘要
已在6名健康男性志愿者中评估了口服甲硫酸地芬尼多的药代动力学参数。药物吸收缓慢（达峰时间=2至4小时），平均半衰期为8.35小时，48小时内尿中回收的药物量占给药剂量的0.6%至7.4%。假设该药物代谢不良，则结果表明其生物利用度较低。
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