单根金纳米棒的体外和体内双光子发光成像
In vitro and in vivo two-photon luminescence imaging of single gold nanorods.
作者信息
Wang Haifeng, Huff Terry B, Zweifel Daniel A, He Wei, Low Philip S, Wei Alexander, Cheng Ji-Xin
机构信息
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
出版信息
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15752-6. doi: 10.1073/pnas.0504892102. Epub 2005 Oct 20.
Abstract
Gold nanorods excited at 830 nm on a far-field laser-scanning microscope produced strong two-photon luminescence (TPL) intensities, with a cos(4) dependence on the incident polarization. The TPL excitation spectrum can be superimposed onto the longitudinal plasmon band, indicating a plasmon-enhanced two-photon absorption cross section. The TPL signal from a single nanorod is 58 times that of the two-photon fluorescence signal from a single rhodamine molecule. The application of gold nanorods as TPL imaging agents is demonstrated by in vivo imaging of single nanorods flowing in mouse ear blood vessels.
摘要
在远场激光扫描显微镜上，830 nm激发的金纳米棒产生了强烈的双光子发光（TPL）强度，其对入射偏振具有cos(4)依赖性。TPL激发光谱可以叠加到纵向等离子体激元带上，表明等离子体增强的双光子吸收截面。单个纳米棒的TPL信号是单个罗丹明分子双光子荧光信号的58倍。通过对在小鼠耳部血管中流动的单个纳米棒进行体内成像，证明了金纳米棒作为TPL成像剂的应用。
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