猪布鲁氏菌两种高氧亲和力末端氧化酶在体外和巨噬细胞内增殖中的差异利用
Differential use of the two high-oxygen-affinity terminal oxidases of Brucella suis for in vitro and intramacrophagic multiplication.
作者信息
Loisel-Meyer Séverine, Jiménez de Bagüés Maria Pilar, Köhler Stephan, Liautard Jean-Pierre, Jubier-Maurin Véronique
机构信息
INSERM U-431, Université Montpellier II, Place E. Bataillon, CC100, 34095 Montpellier Cedex 05, France.
出版信息
Infect Immun. 2005 Nov;73(11):7768-71. doi: 10.1128/IAI.73.11.7768-7771.2005.
Abstract
Expression of the high-oxygen-affinity cytochrome cbb3 and cytochrome bd ubiquinol oxidases of Brucella suis was studied in vitro and in the intramacrophagic niche, which was previously proposed to be oxygen limited. The cytochrome cbb3 oxidase was exclusively expressed in vitro, whereas the cytochrome bd oxidase was preferentially used inside macrophages and contributed to intracellular bacterial replication.
摘要
对猪布鲁氏菌高氧亲和力细胞色素cbb3和细胞色素bd泛醇氧化酶的表达进行了体外研究以及在巨噬细胞内生态位中的研究，此前有研究认为巨噬细胞内生态位存在氧限制。细胞色素cbb3氧化酶仅在体外表达，而细胞色素bd氧化酶在巨噬细胞内被优先利用，并有助于细胞内细菌的复制。
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