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松质骨应变表明在受限髁膝关节中进行干细胞增强的有效性。

Cancellous bone strains indicate efficacy of stem augmentation in constrained condylar knees.

作者信息

Rawlinson Jeremy J, Peters Lance E, Campbell Deirdre A, Windsor Russell, Wright Timothy M, Bartel Donald L

机构信息

Cornell University, Ithaca, NY 14850, USA.

出版信息

Clin Orthop Relat Res. 2005 Nov;440:107-16. doi: 10.1097/01.blo.0000187340.10003.68.

DOI:10.1097/01.blo.0000187340.10003.68
PMID:16239792
Abstract

Modular augmented stems of a constrained condylar knee implant are intended to improve tibial fixation under increased varus/valgus loads, but conflicting studies have not yet indicated the factors determining stem usage and performance. To address this, we combined a paired-tibiae, cadaveric experiment of unstemmed and stemmed tibial components with specimen-specific computational models. We hypothesized that the stem would improve implant stability by decreasing implant motion and compressive strains in the proximal cancellous bone due to load transfer by the stem. The models also would indicate the important factors governing stem performance. Large variations of the displacements arose because of loading and biologic variability indicating the inconclusive effects of a stem. Despite these variations, the models showed that a stem augment consistently decreased the strains (30%-50%) in the bone beneath the tray. In tibiae of sufficient stiffness, the supporting cancellous bone did not approach yield, suggesting that a stem augment may not always be necessary. On the other hand, tibial specimens with reduced bone quality and lower stiffness benefited from a stem augment that transferred load to the distal cortical bone. Therefore, patient selection and proper sizing of the implant were identified as important factors in the analyses.

摘要

受限髁膝关节假体的模块化增强柄旨在改善在增加的内翻/外翻负荷下的胫骨固定,但相互矛盾的研究尚未表明决定柄的使用和性能的因素。为了解决这个问题,我们将无柄和有柄胫骨组件的配对胫骨尸体实验与特定标本的计算模型相结合。我们假设,柄将通过减少由于柄的负荷传递而导致的近端松质骨中的植入物运动和压缩应变来提高植入物稳定性。这些模型还将表明决定柄性能的重要因素。由于加载和生物变异性,位移出现了很大变化,这表明柄的效果尚无定论。尽管存在这些变化,但模型显示,增强柄始终能降低托盘下方骨中的应变(30%-50%)。在具有足够刚度的胫骨中,支撑性松质骨未接近屈服,这表明增强柄可能并非总是必要的。另一方面,骨质量降低和刚度较低的胫骨标本受益于将负荷转移至远端皮质骨的增强柄。因此,患者选择和植入物的适当尺寸确定为分析中的重要因素。

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