Pietropaolo Valeria, Fioriti Daniela, Mischitelli Monica, Anzivino Elena, Santini Manuela, Millefiorini Enrico, Di Rezze Simone, Degener Anna Marta
Department of Public Health Sciences, La Sapienza University, Rome, Italy.
New Microbiol. 2005 Jul;28(3):199-203.
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system whose pathological features consist of white matter plaques of primary demyelinization and loss of oligodendrocytes. Various risk factors have been associated with MS susceptibility. We have focused this study on different viruses. In particular in the present study we used PCR to search for the genomic DNA of HHV-1, HHV-2, HHV-8, BKV and JCV in urine and peripheral blood mononuclear cells (PBMC) samples from 44 relapsing-remitting MS (RRMS) patients. No viral DNA was found in any urine sample, whereas 29.5% of RRMS PBMC samples were positive. It is suggestive that Human herpesviruses (HHV-1 and HHV-8) were constantly present in all positive samples, indicating that viral agents could contribute to create the demyelination plaques and cause MS.
多发性硬化症（MS）是一种中枢神经系统的炎症性疾病，其病理特征包括原发性脱髓鞘的白质斑块和少突胶质细胞的丧失。多种风险因素与MS易感性相关。我们将这项研究聚焦于不同的病毒。特别是在本研究中，我们使用聚合酶链反应（PCR）在44例复发缓解型MS（RRMS）患者的尿液和外周血单核细胞（PBMC）样本中寻找HHV-1、HHV-2、HHV-8、BK病毒（BKV）和JC病毒（JCV）的基因组DNA。在任何尿液样本中均未发现病毒DNA，而29.5%的RRMS患者PBMC样本呈阳性。这表明人类疱疹病毒（HHV-1和HHV-8）在所有阳性样本中持续存在，表明病毒因子可能导致脱髓鞘斑块的形成并引发MS。
