囊性纤维化患者中铜绿假单胞菌的营养缺陷型

Auxotrophy of Pseudomonas aeruginosa in cystic fibrosis.

作者信息

Taylor R F, Hodson M E, Pitt T L

机构信息

Royal Brompton and National Heart Hospital, London, UK.

出版信息

FEMS Microbiol Lett. 1992 May 1;71(3):243-6. doi: 10.1016/0378-1097(92)90716-2.

DOI:10.1016/0378-1097(92)90716-2

PMID:1624122

Abstract

Seventy-four of 403 (18.4%) sputum isolates of Pseudomonas aeruginosa from 49 of 136 (36.0%) adults with cystic fibrosis (CF) were auxotrophic mutants. Two of 11 (18.2%) isolates of P. aeruginosa taken from patients with non-CF bronchiectasis were also auxotrophic. All 99 strains taken from non-bronchiectatic sources were prototrophic. Forty-six of 55 (83.6%) CF auxotrophs required one or more of 36 growth factors tested; the requirements for the remaining 9 isolates were not identified. Methionine was the sole factor required by 17 of 22 (77.3%) isolated which depended on a single factor. We conclude that auxotrophy is a feature of P. aeruginosa infection in cystic fibrosis.

摘要

在136名成年囊性纤维化（CF）患者中，有49名（36.0%）患者的痰液分离出铜绿假单胞菌，其中403株中有74株（18.4%）为营养缺陷型突变体。从非CF支气管扩张症患者中分离出的11株铜绿假单胞菌中有2株（18.2%）也是营养缺陷型。从非支气管扩张症来源获取的所有99株菌株都是原养型。55株CF营养缺陷型菌株中有46株（83.6%）需要所测试的36种生长因子中的一种或多种；其余9株菌株的需求未明确。蛋氨酸是22株（77.3%）依赖单一因子的分离菌株中17株所需的唯一因子。我们得出结论，营养缺陷是囊性纤维化中铜绿假单胞菌感染的一个特征。