HIV阳性患者直肠活检标本中神经内分泌细胞的耗竭。
Depletion of neuroendocrine cells in rectal biopsy specimens from HIV positive patients.
作者信息
McCullough J B, Batman P A, Miller A R, Sedgwick P M, Griffin G E
机构信息
Department of Histopathology, Bradford Royal Infirmary.
出版信息
J Clin Pathol. 1992 Jun;45(6):524-7. doi: 10.1136/jcp.45.6.524.
AIMS
To compare the density of neuroendocrine cells in rectal biopsy specimens from human immunodeficiency virus (HIV) infected individuals with that of a control group.
METHODS
Neuroendocrine cells in rectal biopsies were identified using an immunohistochemical stain for chromogranin and subsequently quantified using a method of linear intercept.
RESULTS
Neuroendocrine cells were found to be significantly decreased in the HIV positive group.
CONCLUSIONS
Loss of neuroendocrine cells may contribute to apoptotic bodies seen in this condition. This could be related to infection of these cells with HIV and could contribute to diarrhoeal disease in HIV infection.
目的
比较人类免疫缺陷病毒（HIV）感染者直肠活检标本中神经内分泌细胞的密度与对照组的密度。
方法
使用嗜铬粒蛋白免疫组织化学染色鉴定直肠活检中的神经内分泌细胞，随后采用线性截距法进行定量分析。
结果
发现HIV阳性组的神经内分泌细胞显著减少。
结论
神经内分泌细胞的缺失可能导致在这种情况下出现凋亡小体。这可能与这些细胞被HIV感染有关，并可能导致HIV感染中的腹泻病。
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