Adachi A, Koenig S, Gendelman H E, Daugherty D, Gattoni-Celli S, Fauci A S, Martin M A
J Virol. 1987 Jan;61(1):209-13. doi: 10.1128/JVI.61.1.209-213.1987.
Thirteen adherent human non-lymphocyte cell lines were tested for their susceptibility to infection by human immunodeficiency virus. Productive infection could be demonstrated in three of five colorectal carcinoma cell lines examined; the other eight human non-lymphocyte cell lines were uninfectible. A susceptible colon carcinoma cell line (HT29), as well as normal colonic mucosa, was shown to contain a 3.0-kilobase species of poly(A)+ CD4 RNA, whereas uninfectible colon carcinoma and rhabdomyosarcoma cell lines synthesized no detectable T4 RNA. A persistently infected colon carcinoma cell line was established that continued to produce progeny human immunodeficiency virus for more than 10 weeks postinfection.
对13种贴壁生长的人非淋巴细胞系进行了人免疫缺陷病毒感染易感性检测。在所检测的5种结肠癌细胞系中，有3种能发生增殖性感染；另外8种人非淋巴细胞系则不能被感染。一种易感结肠癌细胞系（HT29）以及正常结肠黏膜显示含有一种3.0千碱基的多聚腺苷酸加尾CD4 RNA，而不能被感染的结肠癌细胞系和横纹肌肉瘤细胞系则未合成可检测到的T4 RNA。建立了一种持续感染的结肠癌细胞系，该细胞系在感染后10周以上仍继续产生人免疫缺陷病毒子代。
