Negroni E, Butler-Browne G S, Mouly V
Cytosquelette et Développement, FRE 2853, Faculté de Médecine Pitié-Salpétrière, Université Pierre et Marie Curie, 105, boulevard de l'Hôpital, 75013 Paris, France.
Pathol Biol (Paris). 2006 Mar;54(2):100-8. doi: 10.1016/j.patbio.2005.09.001. Epub 2005 Oct 21.
Human skeletal muscle has been considered as an ideal target for cell-mediated therapy. However, the positive results obtained in dystrophic animal models using the resident precursor satellite cell population have been followed by discouraging evidences obtained in the clinical trials involving Duchenne muscular dystrophy patients. This text reviews the recent advances that many groups have achieved to identify from the stem cell compartment putative candidates for cell therapy. We focused our attention on stem cells with myogenic potential which might be able to improve transplantation efficiency and therefore could be used as a therapeutic tool for neuromuscular diseases.
人类骨骼肌一直被视为细胞介导治疗的理想靶点。然而，在使用驻留前体卫星细胞群体的营养不良动物模型中取得的积极成果，随后在涉及杜兴氏肌营养不良症患者的临床试验中却得到了令人沮丧的证据。本文回顾了许多研究小组在从干细胞区室中识别细胞治疗潜在候选者方面取得的最新进展。我们将注意力集中在具有生肌潜力的干细胞上，这些干细胞可能能够提高移植效率，因此可作为治疗神经肌肉疾病的工具。
